- Appearance:White to off-white powder
- Purity:≥99% by TLC
1-deoxynojirimycin (DNJ), also called duvoglustat or moranolin. 1-deoxynojirimycin derived from Mulberry leaves, is a potent inhibitor of intestinal α-glycosidases, which acts as an antihyperglycemic agent by slowing the rate of carbohydrate degradation to monosaccharides. Deoxynojirimycin inhibits α-glucosidase I and II.
Inhibits human immunodeficiency virus envelope glycoprotein-mediated membrane fusion at the CXCR4 binding step. May be used to produce an affinity ligand for purifying glucosidase 1. Deoxynojirimycin was used to inhibit ER glucosidases I and II allowing for the discovery of a second mechanism for deglucosylation of N-linked oligosaccharides in PhaR1.7, a mouse lymphoma cell line.
Not for human therapeutic use or for medicinal purposes. For research applications only.
|Handling||Ensure adequate ventilation, especially in confined areas. Use personal protective equipment as required. Use with local exhaust ventilation. Do not breathe dust/fume/gas/mist/vapors/spray.|