1-Deoxynojirimycin
SKU
D-1157
- CAS:19130-96-2
- Formula:C6H13NO4
- MW:163.2
- Appearance:White Crystalline Solid
- Purity:>98%
SDS
CofA
1-deoxynojirimycin (DNJ), also called duvoglustat or moranolin. 1-deoxynojirimycin derived from Mulberry leaves, is a potent inhibitor of intestinal α-glycosidases, which acts as an antihyperglycemic agent by slowing the rate of carbohydrate degradation to monosaccharides. Deoxynojirimycin inhibits α-glucosidase I and II. Inhibits human immunodeficiency virus envelope glycoprotein-mediated membrane fusion at the CXCR4 binding step. May be used to produce an affinity ligand for purifying glucosidase 1. Deoxynojirimycin was used to inhibit ER glucosidases I and II allowing for the discovery of a second mechanism for deglucosylation of N-linked oligosaccharides in PhaR1.7, a mouse lymphoma cell line.
More Information
Alternate Name/Synonyms
dNM, Duvoglustat, moranolin
SKU
D-1157
CAS #
19130-96-2
Chemical Name
5-AMINO-1,5-DIDEOXY-D-GLUCOPYRANOSE
Chemical Formula
C6H13NO4
Molecular Weight
163.2
Appearance
White Crystalline Solid
Purity
>98%
Solubility
May be dissolved in water (25 mg/ml)
Storage Temp
-20°C
THERAPEUTIC AREA
Infectious Diseases
USE
An alpha-glucosidase inhibitor with antiviral action in anti-HIV activity
MDL NUMBER
MFCD00063474
CHEMACX
X1794671-7
INCHI
InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1
SMILES
C1[C@@H]([C@H]([C@@H]([C@H](N1)CO)O)O)O
RTECS
TN4350300
Handling
Store in Tightly Sealed Vial
Special Shipping
Yes
Certificate of Analysis 1
Certificate of Analysis 2
Certificate of Analysis 3
| Handling | Store in Tightly Sealed Vial |
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