1-Deoxynojirimycin

SKU
D-1157
  • CAS:19130-96-2
  • Formula:C6H13NO4
  • MW:163.17
  • Appearance:White to off-white powder
  • Purity:≥99% by TLC
Product Name Qty
1-Deoxynojirimycin
25 mg
$124.00
1-Deoxynojirimycin
50 mg
$214.00
1-Deoxynojirimycin
100 mg
$375.00
1-Deoxynojirimycin
250 mg
$545.00

Description

1-deoxynojirimycin (DNJ), also called duvoglustat or moranolin.  1-deoxynojirimycin derived from Mulberry leaves, is a potent inhibitor of intestinal α-glycosidases, which acts as an antihyperglycemic agent by slowing the rate of carbohydrate degradation to monosaccharides. Deoxynojirimycin inhibits α-glucosidase I and II.

Inhibits human immunodeficiency virus envelope glycoprotein-mediated membrane fusion at the CXCR4 binding step. May be used to produce an affinity ligand for purifying glucosidase 1. Deoxynojirimycin was used to inhibit ER glucosidases I and II allowing for the discovery of a second mechanism for deglucosylation of N-linked oligosaccharides in PhaR1.7, a mouse lymphoma cell line.

 

Not for human therapeutic use or for medicinal purposes. For research applications only.

More Information
Alternate Name/Synonyms
dNM; Duvoglustat; Moranoline; Deoxynojirimycin; Moranolin
SKU
D-1157
CAS #
19130-96-2
Chemical Name
(2R,3R,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-triol
Chemical Formula
C6H13NO4
Molecular Weight
163.17
Appearance
White to off-white powder
Purity
≥99% by TLC
Solubility
DMSO: Clear colorless solution at 10 mg/mL. Water: Clear colorless solution at 40 mg/mL.
Melting Point
195-200ºC
Storage Temp
-20ºC
THERAPEUTIC AREA
Infectious Diseases
USE
An alpha-glucosidase inhibitor with antiviral action in anti-HIV activity
MDL NUMBER
MFCD00063474
CHEMACX
X1794671-7
INCHI
InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1
SMILES
C1[C@@H]([C@H]([C@@H]([C@H](N1)CO)O)O)O
RTECS
TN4350300
Handling
Ensure adequate ventilation, especially in confined areas. Use personal protective equipment as required. Use with local exhaust ventilation. Do not breathe dust/fume/gas/mist/vapors/spray.
Special Shipping
Yes
Certificate of Analysis 1
Certificate of Analysis 2
Certificate of Analysis 3
HandlingEnsure adequate ventilation, especially in confined areas. Use personal protective equipment as required. Use with local exhaust ventilation. Do not breathe dust/fume/gas/mist/vapors/spray.
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