17-DMAG

SKU
A-1298
  • CAS:467214-20-6
  • Formula:C32H48N4O8
  • MW:616.8 Da
  • Appearance:Purple powder
  • Purity:98% by TLC

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Product Name Qty
17-DMAG
1 mg
$55.83
17-DMAG
5 mg
$145.17

Description

17-DMAG binds to Hsp90 and alters its function. A water soluble cell-permeable analog of Geldanamycin and 17-AAG, 17-DMAG binds to the APTase site of human Hsp90 with high affinity, has cytotoxic activity against many cancer cell lines, and acts as angiogenesis inhibitor.Treatment with 17-DMAG significantly reduced the hemorrhage-induced increases in iNOS protein, jejunal alteration, and IL-10 concentrations, but 17-DMAG did not affect the hemorrhage-induced increases in p53 and IL-6 concentration.17-DMAG diminishes hemorrhage-induced small intestine injury by elevating Bcl-2 protein and inhibiting iNOS pathway, TNF-alpha increase, and caspase-3 activation. HSP90 inhibits, 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin(DMAG) to increase the radiosensitivity of tumor cells in vitro. HSP90 inhibitor, 17-DMAG, enhances radiosensitivity of human cancer cells.

More Information
Alternate Name/Synonyms
alvespimycin; 17-dimethylaminoethylamino-17-demethoxygeldanamycin; 17-Dimethylaminogeldanamycin; NSC707545
SKU
A-1298
CAS #
467214-20-6
Chemical Name
[(4E,6Z,8S,9S,10E,12S,13R,14S,16R)-19-[2-(dimethylamino)ethylamino]-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl] carbamate
Chemical Formula
C32H48N4O8
Molecular Weight
616.8 Da
Appearance
Purple powder
Purity
98% by TLC
Solubility
Soluble in DMSO, Methanol, Ethanol
Melting Point
N/A
Preparation
Clear purple solution at 10mg 17DMAG in 1ml of Methanol, or 25mg 17DMAG in 1ml DMSO
Storage Temp
-20°C
THERAPEUTIC AREA
Oncological Disorders
USE
17-DMAG is used to inhibit cancer growth and to promote apoptosis in multiple cell lines
Merck Index
N/A
MDL NUMBER
MFCD08457919
CHEMACX
X1578552-3
INCHI
InChI=1S/C32H48N4O8/c1-18-14-22-27(34-12-13-36(5)6)24(37)17-23(29(22)39)35-31(40)19(2)10-9-11-25(42-7)30(44-32(33)41)21(4)16-20(3)28(38)26(15-18)43-8/h9-11,16-18,20,25-26,28,30,34,38H,12-15H2,1-8H3,(H2,33,41)(H,35,40)/b11-9-,19-10+,21-16+/t18-,20+,25+,26+,28-,30+/m1/s1
SMILES
C[C@H]1C[C@@H]([C@@H]([C@H](/C=C(/[C@@H]([C@H](/C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCCN(C)C)/C)OC)OC(=O)N)C)C)O)OC
Peptide sequence
Not Applicable
RTECS
N/A
UN #'S
N/A
PACKING GROUP
N/A
HAZARD CLASS
N/A
Handling
Handle in accordance with good industrial hygiene and safety practice. Corrosive hazard. Wear protective gloves/clothing and eye/face protection
Certificate of Analysis 1
Certificate of Analysis 2
Certificate of Analysis 3
Handling Handle in accordance with good industrial hygiene and safety practice. Corrosive hazard. Wear protective gloves/clothing and eye/face protection
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