Quick Order Pad
Your Shopping Cart is Empty
Hello, Sign In

17-DMAG, 1 MG

Price$ 67.50
  • SKU: A-1298-1MG
  • Pack Size: 1 MG
Quantity
-
+

Frequently Bought Together

Total price: $ 189.50

This item: 17-DMAG, 1 MG $ 67.50

Mycophenolic Acid, 10 MG $ 22.75

A23187, Free Acid, 5 MG $ 99.25

Alvespimycin; 17-Dimethylaminoethylamino-17- demethoxygeldanamycin

467214-20-6

616.8

C32H48N4O8

DMSO, Ethanol

-20°C


17-DMAG binds to Hsp90 and alters its function. A water soluble cell-permeable analog of Geldanamycin and 17-AAG, 17-DMAG binds to the APTase site of human Hsp90 with high affinity, has cytotoxic activity against many cancer cell lines, and acts as angiogenesis inhibitor.

Treatment with 17-DMAG significantly reduced the hemorrhage-induced increases in iNOS protein, jejunal alteration, and IL-10 concentrations, but 17-DMAG did not affect the hemorrhage-induced increases in p53 and IL-6 concentration.17-DMAG diminishes hemorrhage-induced small intestine injury by elevating Bcl-2 protein and inhibiting iNOS pathway, TNF-alpha increase, and caspase-3 activation.

HSP90 inhibits, 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin(DMAG) to increase the radiosensitivity of tumor cells in vitro. HSP90 inhibitor, 17-DMAG, enhances radiosensitivity of human cancer cells.

 

0.1 lbs



Research or further manufacturing use only, not for food or drug use.

Product Recommendations