2,5-Dimethyl-celecoxib

SKU
D-2593
  • CAS:457639-26-8
  • Formula:C18H16F3N3O2S
  • MW:395.40
  • Appearance:White to off-white powder
Product Name Qty
2,5-Dimethyl Celecoxib
25 mg
$342.61

Celecoxib, and the inactive analog 2′,5′-dimethyl celecoxib both induce apoptosis in a many cancer cell lines by down-regulating the expression of survivin. This activiy is mediated via an AKT mediated pathway, and is unique to this class of cyclo-oxygenase inhibitors, as non-selective NSAIDs or other COX-2 specific inhibitors such as rofecoxib, do not effect survivin expression. Unlike celecoxib, 2′,5′-dimethyl celecoxib is devoid of any inhibitory activity against COX-2.

More Information
SKU
D-2593
CAS #
457639-26-8
Chemical Formula
C18H16F3N3O2S
Molecular Weight
395.40
Appearance
White to off-white powder
Hazard Image
Yes
GHS PICTOGRAMS
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