4-Bromo-A23187

SKU
A-1130
  • CAS:76455-48-6
  • Formula:C29H36BrN3O6
  • MW:602.50 Da
  • Appearance:Slight yellow crystals
  • Purity:>98%

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1

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Product Name Qty
4-Bromo-A23187
1 mg
$100.69
4-Bromo-A23187
5 mg
$388.20

Description

4-Bromo-A23187 is a halogenated analog and divalent ionophore of A23187. Nonfluorescent calcium ionophore used as a calibration standard for determining cytoplasmic calcium ions by fluorescent probes.

Studies conducted in quin-2-loaded thymic lymphocytes of rat, 4-Bromo-A23187 has shown to saturate Ca2+ sites. This activity of 4-Bromo-A23187 has been suggested to be identical to ionomycin. Affinity towards Zn2+ and Mn2+ transportation, has been used for investigating cell regulation by Zn2+ and Mn2+.


Not for human therapeutic use or for medicinal purposes. For research applications only.

More Information
Alternate Name/Synonyms
4-Bromocalcimycin; 4-Bromo-antibiotic A23187; 4-Bromo-A23187; 4br-a23187
SKU
A-1130
CAS #
76455-48-6
Chemical Name
6-bromo-5-(methylamino)-2-[[(2S,3R,5R,6S,8R,9R)-3,5,9-trimethyl-2-[(2S)-1-oxo-1-(1H-pyrrol-2-yl)propan-2-yl]-1,7-dioxaspiro[5.5]undecan-8-yl]methyl]-1,3-benzoxazole-4-carboxylic acid
Chemical Formula
C29H36BrN3O6
Molecular Weight
602.50 Da
Appearance
Slight yellow crystals
Purity
>98%
Solubility
DMSO, Methanol, Dichloromethane. Clear colorless solution at 10 mg/mL.
Melting Point
316-319 °C
Storage Temp
+4°C
USE
Nonfluorescent calcium ionophore used as a calibration standard for determining cytoplasmic calcium ions by fluorescent probes.
MDL NUMBER
MFCD00077667
CHEMACX
X1087576-2
INCHI
InChI=1S/C29H36BrN3O6/c1-14-8-9-29(16(3)11-15(2)27(39-29)17(4)26(34)19-7-6-10-32-19)38-20(14)13-22-33-25-21(37-22)12-18(30)24(31-5)23(25)28(35)36/h6-7,10,12,14-17,20,27,31-32H,8-9,11,13H2,1-5H3,(H,35,36)/t14-,15-,16-,17-,20-,27+,29+/m1/s1
SMILES
C[C@@H]1CC[C@]2([C@@H](C[C@H]([C@H](O2)[C@H](C)C(=O)c3ccc[nH]3)C)C)O[C@@H]1Cc4nc5c(o4)cc(c(c5C(=O)O)NC)Br
Peptide sequence
Not Applicable
Handling
Avoid contact with skin, eyes or clothing. Use personal protective equipment as required. Wash contaminated clothing before reuse. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this product.
Citations
NEUROBIOLOGY OF DISEASE: No Consistent Bioenergetic Defects in Presynaptic Nerve Terminals Isolated from Mouse Models of Alzheimer's Disease Sung W. Choi, Akos A. Gerencser, Ryan Ng, James M. Flynn, Simon Melov, Steven R. Danielson, Bradford W. Gibson, David G. Nicholls, Dale E. Bredesen, and Martin D. Brand J. Neurosci., Nov 2012; 32: 16775 - 16784.
Citations_Hyperlink
http://www.jneurosci.org/cgi/content/abstract/32/47/16775?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&andorexacttitle=and&andorexacttitleabs=and&fulltext=AG+Scientific&andorexactfulltext=phrase&searchid=1&FIRSTINDEX=0&fdate=1/1/2000&resourcetype=HWCIT
Certificate of Analysis 1
Certificate of Analysis 2
Certificate of Analysis 3
GHS PICTOGRAMS
Handling Avoid contact with skin, eyes or clothing. Use personal protective equipment as required. Wash contaminated clothing before reuse. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this product.
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