4-Bromo-A23187

SKU
A-1130
  • CAS:76455-48-6
  • Formula:C29H36BrN3O6
  • MW:602.5
  • Appearance:Slight yellow crystals
  • Purity:99%

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Product Name Qty
4-Bromo-A23187
1 mg
$98.72
4-Bromo-A23187
5 mg
$380.59

4-Bromo-A23187 is a halogenated analog and divalent ionophore of A23187. Nonfluorescent calcium ionophore used as a calibration standard for determining cytoplasmic calcium ions by fluorescent probes. Studies conducted in quin-2-loaded thymic lymphocytes of rat, 4-Bromo-A23187 has shown to saturate Ca2+ sites. This activity of 4-Bromo-A23187 has been suggested to be identical to ionomycin. Affinity towards Zn2+ and Mn2+ transportation, has been used for investigating cell regulation by Zn2+ and Mn2+.

 

 

 

More Information
Alternate Name/Synonyms
4-Bromocalcimycin,4-Bromo-antibiotic A23187, 4-Bromo-A23187, Calcium Ionophore
SKU
A-1130
CAS #
76455-48-6
Chemical Name
6-BROMO-5-(METHYLAMINO)-2-[[(2S,3R,5R,6S,8R,9R)-3,5,9-TRIMETHYL-2-[(2S)-1-OXO-1-(1H-PYRROL-2-YL)PROPAN-2-YL]-1,7-DIOXASPIRO[5.5]UNDECAN-8-YL]METHYL]-1,3-BENZOXAZOLE-4-CARBOXYLIC ACID
Chemical Formula
C29H36BrN3O6
Molecular Weight
602.5
Appearance
Slight yellow crystals
Purity
99%
Solubility
CH2Cl2: Clear, colorless solution at 10 mg/ml.
Melting Point
316-319 °C
Storage Temp
+4°C
THERAPEUTIC AREA
Not Available
USE
Nonfluorescent calcium ionophore used as a calibration standard for determining cytoplasmic calcium ions by fluorescent probes
MDL NUMBER
MFCD00077667
CHEMACX
X1087576-2
INCHI
InChI=1S/C29H36BrN3O6/c1-14-8-9-29(16(3)11-15(2)27(39-29)17(4)26(34)19-7-6-10-32-19)38-20(14)13-22-33-25-21(37-22)12-18(30)24(31-5)23(25)28(35)36/h6-7,10,12,14-17,20,27,31-32H,8-9,11,13H2,1-5H3,(H,35,36)/t14-,15-,16-,17-,20-,27+,29+/m1/s1
SMILES
C[C@@H]1CC[C@]2([C@@H](C[C@H]([C@H](O2)[C@H](C)C(=O)c3ccc[nH]3)C)C)O[C@@H]1Cc4nc5c(o4)cc(c(c5C(=O)O)NC)Br
Peptide sequence
Not Applicable
RTECS
Not Applicable
UN #'S
Not Applicable
PACKING GROUP
Not Applicable
HAZARD CLASS
Not Applicable
Handling
Warning.Toxic. May be Carcinogenic. Wear gloves/mask when handling product. Avoid contact by all means of exposure. Protect from Light and moisture.
Citations
NEUROBIOLOGY OF DISEASE: No Consistent Bioenergetic Defects in Presynaptic Nerve Terminals Isolated from Mouse Models of Alzheimer's Disease Sung W. Choi, Akos A. Gerencser, Ryan Ng, James M. Flynn, Simon Melov, Steven R. Danielson, Bradford W. Gibson, David G. Nicholls, Dale E. Bredesen, and Martin D. Brand J. Neurosci., Nov 2012; 32: 16775 - 16784.
Citations_Hyperlink
http://www.jneurosci.org/cgi/content/abstract/32/47/16775?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&andorexacttitle=and&andorexacttitleabs=and&fulltext=AG+Scientific&andorexactfulltext=phrase&searchid=1&FIRSTINDEX=0&fdate=1/1/2000&resourcetype=HWCIT
Certificate of Analysis 1
Certificate of Analysis 2
Certificate of Analysis 3
GHS PICTOGRAMS
Handling Warning.Toxic. May be Carcinogenic. Wear gloves/mask when handling product. Avoid contact by all means of exposure. Protect from Light and moisture.
UN #'S Not Applicable
Packing Group Not Applicable
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