ABT-888

SKU
A-2178
  • CAS:912445-05-7
  • Formula:C13H16N4O.2HCl
  • MW:317.21
  • Appearance:Coloreless to white crystalline Solid
  • Purity:98% by HPLC
Product Name Qty
ABT-888
1 mg
$217.76
ABT-888
5 mg
$776.13

Potent inhibitor of PARP-1 and PARP-2 (potency 5 nM in vitro). Does not inhibit other NAD-binding enzymes. Has minimal CYP450 inhibition and induction. Shows broad spectrum of chemo- and radio-potentiation. Does not show inherent cytotoxicity and shows no single agent activity in tumor models.

More Information
Alternate Name/Synonyms
2-[(2R)-2-Methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide dihydrochloride
SKU
A-2178
CAS #
912445-05-7
Chemical Name
2-[(2R)-2-Methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide . dihydrochloride
Chemical Formula
C13H16N4O.2HCl
Molecular Weight
317.21
Appearance
Coloreless to white crystalline Solid
Purity
98% by HPLC
Solubility
Soluble in DMSO and H2O
Stability
N/A
Storage Temp
-20°C
THERAPEUTIC AREA
Oncological Disorders
USE
ABT-888 has been shown to inhibit PARP-1 and PARP-2 for treatment of colon cancer
MDL NUMBER
MFCD12407402
CHEMACX
X1812318-5
INCHI
InChI=1S/C13H16N4O.2ClH/c1-13(6-3-7-15-13)12-16-9-5-2-4-8(11(14)18)10(9)17-12;;/h2,4-5,15H,3,6-7H2,1H3,(H2,14,18)(H,16,17);2*1H/t13-;;/m1../s1
SMILES
C[C@@]1(CCCN1)c2[nH]c3cccc(c3n2)C(=O)N.Cl.Cl
Handling
Protect from air and moisture
Citations
THIRST AND VOLUME, ELECTROLYTE HOMEOSTASIS: Inhibition of the formation of EETs and 20-HETE with 1-aminobenzotriazole attenuates pressure natriuresis Elisabete A. Dos Santos, Annette J. Dahly-Vernon, Kimberly M. Hoagland, and Richard J. Roman Am J Physiol Regulatory Integrative Comp Physiol, Jul 2004; 287: R58 - R68.
Citations_Hyperlink
http://ajpregu.physiology.org/cgi/reprint/287/1/R58
Promo text for AGS discount
N/A
GHS PICTOGRAMS
Handling Protect from air and moisture
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