AdipoRon

SKU
A-2569
  • CAS:924416-43-3
  • Formula:C27 H28 N2 O3
  • MW:428.529
  • Appearance:White crystalline powder
  • Purity:>98% (TLC); NMR (Conforms)
Product Name Qty
AdipoRon
10 mg
$70.00
AdipoRon
50 mg
$250.00

A novel potent and selective adiponectin (AdipoR1 and AdipoR2) receptor agonist, Kd=1.8 and 3.1 μM respectively. Displayed similar effects to adiponectin in muscle
and liver such as activation of PPARα and AMPK signaling pathways. It also reversed insulin resistance and glucose intolerance in mice on a high-fat diet. It ameliorated diabetes in a genetically obese mouse model and prolonged the shortened lifespan of db/db mice on a high-fat diet. Adiporon attenuates post-ischemic myocardial apoptosis and oxidative stress and improves cardiac function in mouse model of myocardial ischemia/reperfusion injury. Active in vivo.

More Information
SKU
A-2569
CAS #
924416-43-3
Chemical Name
2-(4-benzoylphenoxy)-N-(1-benzylpiperidin-4-yl)acetamide
Chemical Formula
C27 H28 N2 O3
Molecular Weight
428.529
Appearance
White crystalline powder
Purity
>98% (TLC); NMR (Conforms)
Solubility
Soluble in DMSO (86 mg/ml), ethanol (50 mg/ml), and methanol. Insoluble in water.
Melting Point
108-109°C
Storage Temp
Store desiccated as supplied at ambient temperature for up to 1 year. Store solutions at -20°C for up to 2 months.
MDL NUMBER
MFCD08271060
CHEMACX
X7625478-3
INCHI
InChI=1S/C27H28N2O3/c30-26(28-24-15-17-29(18-16-24)19-21-7-3-1-4-8-21)20-32-25-13-11-23(12-14-25)27(31)22-9-5-2-6-10-22/h1-14,24H,15-20H2,(H,28,30)
SMILES
c1ccc(cc1)CN2CCC(CC2)NC(=O)COc3ccc(cc3)C(=O)c4ccccc4
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