Tyrphostin AG 1478

SKU
A-1296
  • CAS:175178-82-2
  • Formula:C16H14CIN3O2
  • MW:315.8
  • Appearance:White Powder
  • Purity:98%

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Product Name Qty
Tyrphostin AG 1478
1 mg
$37.60
Tyrphostin AG 1478
5 mg
$111.64

Tyrphostin AG 1478 has been demonstrated to be a selective and potent inhibitor of Epidermal Growth Factor Receptor (EGFR), with an IC of about 3nMin vitroin a variety of cell lines. In addition to EGFR, AG 1478 also inhibits ErbB4 activation induced by radiation in cancer cells. Testing of it alone or in combination with other treatments to assess anti-tumor and anti-fibrotic effectiveness has yielded promising results.Quantitative analysis of EGFRVIII cellular signaling networks reveals a combinatorial therapeutic strategy for glioblastoma.The antimicrobial peptide cathelicidin enhances activation of lung epithelial cells by LPS.PTK6 Inhibits Down-regulation of EGF Receptor through Phosphorylation of ARAP1. Activation of c-Src/HER1/STAT5b and HER1/ERK1/2 Signaling Pathways and Cell Migration by Hexachlorobenzene in MDA-MB-231 Human Breast Cancer Cell Line. Cross Talk between c-Met and Epidermal Growth Factor Receptor during Retinal Pigment Epithelial Wound Healing.

More Information
Alternate Name/Synonyms
AG 1478
SKU
A-1296
CAS #
175178-82-2
Chemical Name
4-(3-Chloroanillino)-6,7-dimethoxyquinazoline
Chemical Formula
C16H14CIN3O2
Molecular Weight
315.8
Appearance
White Powder
Purity
98%
Solubility
Soluble in Ethanol (25mg/ml), Methanol, and DMSO (25mg/ml)
Storage Temp
-20°C
THERAPEUTIC AREA
Oncological Disorders
USE
EGFR inhibitor AG1478 in ovarian cancer,breast cancer cells
MDL NUMBER
MFCD00270914
CHEMACX
X1096505-2
INCHI
InChI=1S/C16H14ClN3O2/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11/h3-9H,1-2H3,(H,18,19,20)
SMILES
COc1cc2c(cc1OC)ncnc2Nc3cccc(c3)Cl
Handling
Store in Tightly Sealed Vial Protect from Light
Citations
RETINA: Cross Talk between c-Met and Epidermal Growth Factor Receptor during Retinal Pigment Epithelial Wound Healing Ke-Ping Xu and Fu-Shin X. Yu Invest. Ophthalmol. Vis. Sci., May 2007; 48: 2242 - 2248.
Citations_Hyperlink
http://www.iovs.org/cgi/reprint/48/5/2242
Certificate of Analysis 1
Certificate of Analysis 2
Handling Store in Tightly Sealed Vial Protect from Light
Citations Anti-inflammatory mechanism of polyunsaturated fatty acids in Helicobacter pylori-infected gastric epithelial cells
Quantitative analysis of EGFRvIII cellular signaling networks reveals a combinatorial therapeutic strategy for glioblastoma
Sorafenib resistance and JNK signaling in carcinoma during extracellular matrix stiffening
Epidermal growth factor receptor regulates beta-catenin location, stability, and transcriptional activity in oral cancer
The antimicrobial peptide cathelicidin enhances activation of lung epithelial cells by LPS
Clozapine regulation of p90RSK and c-Fos signaling via the ErbB1-ERK pathway is distinct from olanzapine and haloperidol in mouse cortex and striatum
Lysophosphatidic acid-induced transactivation of epidermal growth factor receptor regulates cyclo-oxygenase-2 expression and prostaglandin E(2) release via C/EBPbeta in human bronchial epithelial cells
Docoxahexaenoic Acid Induces Apoptosis of Pancreatic Cancer Cells by Suppressing Activation of STAT3 and NF-κB
Blockade of Ets-1 attenuates epidermal growth factor-dependent collagen loss in human carotid plaque smooth muscle cells
Pro-survival AKT and ERK signaling from EGFR and mutant EGFRvIII enhances DNA double-strand break repair in human glioma cells
MMP-1 and MMP-9 regulate epidermal growth factor-dependent collagen loss in human carotid plaque smooth muscle cells
Quantitative analysis of the EGFRvIII mutant receptor signaling networks in Glioblastoma
Quetiapine and aripiprazole signal differently to ERK, p90RSK and c-Fos in mouse frontal cortex and striatum: role of the EGF receptor
Bioengineered Platforms to Study Carcinoma Cell Response to Drug Treatment
New phosphatidylinositol 3-kinase inhibitors for cancer
Cathelicidins positively regulate pancreatic β-cell functions
A mechanism to explain how regular exercise might reduce the risk for clinical prostate cancer
Cross talk between c-Met and epidermal growth factor receptor during retinal pigment epithelial wound healing
Action of hexachlorobenzene on tumor growth and metastasis in different experimental models
Activation of c-Src/HER1/STAT5b and HER1/ERK1/2 signaling pathways and cell migration by hexachlorobenzene in MDA-MB-231 human breast cancer cell line
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