Tyrphostin AG 1478
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Tyrphostin AG 1478 has been demonstrated to be a selective and potent inhibitor of Epidermal Growth Factor Receptor (EGFR), with an IC of about 3nMin vitroin a variety of cell lines. In addition to EGFR, AG 1478 also inhibits ErbB4 activation induced by radiation in cancer cells. Testing of it alone or in combination with other treatments to assess anti-tumor and anti-fibrotic effectiveness has yielded promising results.Quantitative analysis of EGFRVIII cellular signaling networks reveals a combinatorial therapeutic strategy for glioblastoma.The antimicrobial peptide cathelicidin enhances activation of lung epithelial cells by LPS.PTK6 Inhibits Down-regulation of EGF Receptor through Phosphorylation of ARAP1. Activation of c-Src/HER1/STAT5b and HER1/ERK1/2 Signaling Pathways and Cell Migration by Hexachlorobenzene in MDA-MB-231 Human Breast Cancer Cell Line. Cross Talk between c-Met and Epidermal Growth Factor Receptor during Retinal Pigment Epithelial Wound Healing.
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