Tyrphostin, AG 490

SKU
A-1164
  • CAS:133550-30-8
  • Formula:C17H14N2O3
  • MW:294.3
  • Appearance:Tan Solid
  • Purity: ≥98%

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Product Name Qty
AG 490
25 mg
$222.17
AG 490
10 mg
$88.85
AG 490
50 mg
$353.11
AG 490
5 mg
$52.85

AG-490 is a potent inhibitor of the JAK-2 tyrosine kinase. In acute lymphoblastic leukemia (ALL) cells,which abundantly express JAK-2, AG-490 dosedependently inhibited DNA synthesis, blocked cell growth and induced apoptosis. At 5 μM, AG-490 almost completely blocked the growth of all pre-B ALL cells but had no significant effect on the growth of mitogen-stimulated normal B or T cells, B-cell lymphoma or T-cell leukemia cells. AG-490 does not significantly inhibit other kinases such as Lck, Lyn, Btk, Syk and Src. It blocks interleukin-7-induced JAK kinaseactivity in T-cells (JAK-1, JAK-3) and the consequent phosphorylation of PI-3 kinase. AG-490 is cell permeable and is a valuable tool for studying the cellular role of JAK kinases in signal transduction.

 

 

More Information
Alternate Name/Synonyms
Tyrphostin B42, a-Cyano-(3,4- dihydroxy)-]N-benzylcinnamamide
SKU
A-1164
CAS #
133550-30-8
Chemical Name
N-Benzyl-3,4-dihydroxy-benzylidene
Chemical Formula
C17H14N2O3
Molecular Weight
294.3
Appearance
Tan Solid
Purity
≥98%
Solubility
Soluble in DMSO (25mg/ml) or methanol (10mg/ml).
Stability
N/A
Storage Temp
-20°C
Citations
NEOPLASIA: Constitutively activated STAT3 promotes cell proliferation and survival in the activated B-cell subtype of diffuse large B-cell lymphomas B. Belinda Ding, J. Jessica Yu, Raymond Y.-L. Yu, Lourdes M. Mendez, Rita Shaknovich, Yonghui Zhang, Giorgio Cattoretti, and B. Hilda Ye Blood, Feb 2008; 111: 1515 - 1523.
Citations_Hyperlink
http://bloodjournal.hematologylibrary.org/cgi/reprint/111/3/1515
Certificate of Analysis 1
Certificate of Analysis 2
Certificate of Analysis 3
Promo text for AGS discount
N/A
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