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Tyrphostin, AG 825

SKU
A-1182
  • CAS:149092-50-2
  • Formula:C19H15N3O3S2
  • MW:397.5
  • Appearance:Yellow solid
  • Purity:≥98% (TLC)

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CofA
Product Name Qty
Tyrphostin, AG 825
5 mg
$117.54
Tyrphostin, AG 825
2 mg
$88.85
Tyrphostin, AG 825
10 mg
$353.11
Tyrphostin, AG 825
1 mg
$41.13
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Selective ErbB2 inhibitor (IC50 values are 0.15 and 19 at μM ErbB2 and ErbB1res[ectively). Preferentially triggers p38 MAP kinase-dependent apoptosis in androgen-independent prostate cancer cells.

 

More Information
Alternate Name/Synonyms
Tyrphostin C15
SKU
A-1182
CAS #
149092-50-2
Chemical Name
5-[(Benzothiazol-2-yl)thiomethyl]-4-hydroxy-3-methoxybenzyl-idenecyanoacetamide
Chemical Formula
C19H15N3O3S2
Molecular Weight
397.5
Appearance
Yellow solid
Purity
≥98% (TLC)
Solubility
Soluble in DMSO
Storage Temp
store at -20°C. Stock solutions are stable for up to 3 months when stored at -20°C.
Certificate of Analysis 1
A-1182, F1089.pdf
Certificate of Analysis 2
A-1182, E1390.pdf
Certificate of Analysis 3
A-1182_A-1182,_B1872.pdf
Citations A positive feedback loop between HER2 and ADAM12 in human head and neck cancer cells increases migration and invasion
Jab1 is overexpressed in human breast cancer and is a downstream target for HER-2/neu
Erbb2 suppresses DNA damage-induced checkpoint activation and UV-induced mouse skin tumorigenesis
Erbb2 regulates inflammation and proliferation in the skin after ultraviolet irradiation
Role of CDC25 Phosphatases in Non-Melanoma Skin Cancer
Erbb2 up-regulation of ADAM12 expression accelerates skin cancer progression
Lipid-conjugated telomerase template antagonists sensitize resistant HER2-positive breast cancer cells to trastuzumab
Investigations of the Telomerase Template Antagonist GRN163L and Implications for Augmenting Breast Cancer Therapy
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