AG 879

SKU

A-1198

CAS:148741-30-4
Formula:C₁₈H₂₄N₂OS
MW:316.5
Appearance:Off-white to yellow solid
Purity:≥98%

SDS

CofA

Product Name	Qty
AG 879 1 mg $29.40
AG 879 5 mg $97.56

Details

AG 879 or Tyrphostin AG 879 inhibits the tyrosine kinase activity of nerve growth factor(NGF)-dependent TrKA tyrosine phosphorylation in in PC-12 cells (IC₅₀ = ~40 μM), HER2-ErbB2 kinase in several breast and ovarian cancer cell lines (IC₅₀ = ~0.5 μM). It acts as an antiproliferative agent for diseases caused by the hyperactivity of PTKs. AG-879 has also been shown to suppress IL-6-induced tyrosine phosphorylation of STAT3 (IC₅₀ = 15 μM) in schwannoma cells.

Specifications

More Information

Alternate Name/Synonyms

Tyrphostin AG 879

SKU

A-1198

CAS #

148741-30-4

Chemical Name

(3,5-Di-t-butyl-4-hydroxybenzylidene)thiocyanoacetamide alpha-Cyano-(3,5-di-tert.butyl-4-hydroxy)thiocinnamamide

Chemical Formula

C₁₈H₂₄N₂OS

Molecular Weight

316.5

Appearance

Off-white to yellow solid

Purity

≥98%

Solubility

Soluble in DMSO and Ethanol.

Storage Temp

-20°C

Reviews

Safety

Citations