AG 879

SKU
A-1198
  • CAS:148741-30-4
  • Formula:C18H24N2OS
  • MW:316.5
  • Appearance:Off-white to yellow solid
  • Purity:≥98%

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Product Name Qty
AG 879
1 mg
$28.82
AG 879
5 mg
$95.65

AG 879 or Tyrphostin AG 879 inhibits the tyrosine kinase activity of nerve growth factor(NGF)-dependent TrKA tyrosine phosphorylation in in PC-12 cells (IC50 = ~40 μM), HER2-ErbB2 kinase in several breast and ovarian cancer cell lines (IC50 = ~0.5 μM).  It  acts as an antiproliferative agent for diseases caused by the hyperactivity of PTKs. AG-879 has also been shown to suppress IL-6-induced tyrosine phosphorylation of STAT3 (IC50 = 15 μM) in schwannoma cells.

 

 

More Information
Alternate Name/Synonyms
Tyrphostin AG 879
SKU
A-1198
CAS #
148741-30-4
Chemical Name
(3,5-Di-t-butyl-4-hydroxybenzylidene)thiocyanoacetamide alpha-Cyano-(3,5-di-tert.butyl-4-hydroxy)thiocinnamamide
Chemical Formula
C18H24N2OS
Molecular Weight
316.5
Appearance
Off-white to yellow solid
Purity
≥98%
Solubility
Soluble in DMSO and Ethanol.
Stability
N/A
Storage Temp
-20°C
Promo text for AGS discount
N/A
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