- MW:258.23 Da
- Appearance:Tan powder
- Purity:≥98% (HPLC)
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AICAr (AICA-Riboside) is a cell- permeable activator of AMP-activated protein kinase (AMPK), a metabolic sensor involved in both cellular and whole body energy homeostasis. In vivo, pharmacologic activation of AMPK with AICAR mimics exercise and triggers insulin-independent glucose uptake by skeletal muscle. AICAR is able to activate the molecular circuitry of pluripotency in mESC and to induce the expression of several key regulators of pluripotency in somatic cells.
Applications and Effects of AICAr
• AICAr's phosphorylated metabolite activates AMPK and acts as a regulator of de novo purine synthesis.
• Kinase phosphatase biology research.
• Additional Reading: Pathology Research Using Mitophagy Modulators
Not for human therapeutic use or for medicinal purposes. For research applications only.
|Handling||Research use only.|