Several classes of antibiotics have antimalarial effects. Some antibiotics, in particular doxycycline, are used for antimalarial prophylaxis and in combination with more rapidly acting drugs to treat malaria. Multiple antibiotics with antimalarial activity at clinically achievable does exert their antibacterial effects by interfering with targets specific to prokaryotes, including 70S ribosomes and prokaryotic RNA polymerases or DNA gyrases.

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