Alsterpaullone

SKU
A-1136
  • CAS:237430-03-4
  • Formula:C16H11N3O3
  • MW:293.38
  • Appearance:Brown Powder
  • Purity:95%

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Product Name Qty
Alsterpaullone
5 mg
$329.44
Alsterpaullone
1 mg
$69.24
Paullones represent a novel class of small molecule cyclin-dependent kinase (CDK) inhibitors. Alsterpaullone is a potent inhibitor of CDK/cyclin B (IC=0.035M). High in vitro anti-tumor potency.Cell Cycle-regulated Phosphorylation of Hamartin, the Product of the Tuberous Sclerosis Complex 1 Gene, by Cyclin-dependent Kinase 1/Cyclin B.Formation of the head organizer in hydra involves the canonical Wnt pathway.From the Cover: Wnt/-Catenin and noncanonical Wnt signaling interact in tissue evagination in the simple eumetazoan Hydra.
More Information
Alternate Name/Synonyms
9-Nitropaullone, 9-Nitro-7,12-dihydroindolo-[3,2-d][1]benzazepin-6(5H)-one
SKU
A-1136
CAS #
237430-03-4
Chemical Name
9-Nitro-7,12-dihydroindolo-[3,2-d][1]benzazepin-6(5H)-one
Chemical Formula
C16H11N3O3
Molecular Weight
293.38
Appearance
Brown Powder
Purity
95%
Solubility
Soluble in DMSO; Insoluble in Water.
Melting Point
238.72 °C
Storage Temp
+4°C
THERAPEUTIC AREA
Neurological Disorders
USE
Alsterpaullone is a potent inhibitor of CDK/cyclin B
MDL NUMBER
MFCD02683579
CHEMACX
X1340840-3
INCHI
InChI=1S/C16H11N3O3/c20-15-8-12-11-7-9(19(21)22)5-6-14(11)18-16(12)10-3-1-2-4-13(10)17-15/h1-7,18H,8H2,(H,17,20)
SMILES
c1ccc2c(c1)-c3c(c4cc(ccc4[nH]3)[N+](=O)[O-])CC(=O)N2
Peptide sequence
Not Applicable
RTECS
Not Applicable
UN #'S
Not Applicable
PACKING GROUP
Not Applicable
HAZARD CLASS
Not Applicable
Handling
Store in Tightly Sealed Vial Protect from Moisture.
Citations
DEVELOPMENTAL BIOLOGY: From the Cover: Wnt/β-Catenin and noncanonical Wnt signaling interact in tissue evagination in the simple eumetazoan Hydra Isabelle Philipp, Roland Aufschnaiter, Suat Özbek, Stefanie Pontasch, Marcell Jenewein, Hiroshi Watanabe, Fabian Rentzsch, Thomas W. Holstein, and Bert Hobmayer PNAS, Mar 2009; 106: 4290 - 4295.
Citations_Hyperlink
http://www.pnas.org/cgi/reprint/106/11/4290
Certificate of Analysis 1
Certificate of Analysis 2
Certificate of Analysis 3
Promo text for AGS discount
N/A
GHS PICTOGRAMS
Handling Store in Tightly Sealed Vial Protect from Moisture.
UN #'S Not Applicable
Packing Group Not Applicable
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