Amikacin

SKU
A-2741
  • CAS:37517-28-5
  • Formula:C22H43N5O13
  • MW:585.6 Da
  • Appearance:White crystalline powder

0

0

0

Product Name Qty
Amikacin
1 g
$147.00
Amikacin
5 g
$625.00

Description

Amikacin, a semi-synthetic aminoglycoside antibiotic derived from kanamycin A. It works by stopping the growth of bacteria. Similar to the other aminoglycosides, amikacin disrupts bacterial protein synthesis by binding to the 30S ribosome of susceptible organisms. Binding interferes with mRNA binding and tRNA acceptor sites leading to the production of non-functional or toxic peptides.

The amino group of amikacin at position 1 is acylated by 4-amino-2-hydroxybutyrate. The presence of the aminohydroxybutyryl group in general prevents the enzymatic modification of amikacin at multiple positions. This antibiotic undergoes acetylation by different types of AAC(6′), as well as by a few other aminoglycoside-modifying enzymes such as AAC(2′), APH(2"), and ANT(2"). The activity of the parent antibiotic is not compromised by this synthetic alteration because the aminohydroxybutyryl group does not interfere with binding to the A-site of rRNA.

Amikacin is most often used for treating severe infection with multidrug-resistant, aerobic Gram-negative bacteria, especially PseudomonasAcinetobacterEnterobacterE. coliProteusKlebsiella, and Serratia. The only Gram-positive bacteria that amikacin strongly affects are Staphylococcus and Nocardia


Not for human therapeutic use or for medicinal purposes. For research applications only.

More Information
Alternate Name/Synonyms
Amicacin; Amikacine; Amikacinum; Amikacillin
SKU
A-2741
CAS #
37517-28-5
Chemical Name
(2S)-4-amino-N-[(1R,2S,3S,4R,5S)-5-amino-2-[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4-[(2R,3R,4S,5S,6R)-6-(aminomethyl)-3,4,5-trihydroxyoxan-2-yl]oxy-3-hydroxycyclohexyl]-2-hydroxybutanamide
Chemical Formula
C22H43N5O13
Molecular Weight
585.6 Da
Appearance
White crystalline powder
Solubility
Water
Storage Temp
2-8°C
THERAPEUTIC AREA
Bacterial infections
USE
Aminoglycoside antibiotic used to treat different types of bacterial infections.
Handling
Use in a chemical fume hood, with air supplied by an independent system. Avoid inhalation, contact with eyes, skin and clothing. Avoid the formation of dust and aerosols. Use in a well-ventilated area. Keep away from sources of ignition. Avoid prolonged or repeated exposure.
Hazard Image
Yes
Certificate of Analysis 1
Certificate of Analysis 2
Certificate of Analysis 3
Handling Use in a chemical fume hood, with air supplied by an independent system. Avoid inhalation, contact with eyes, skin and clothing. Avoid the formation of dust and aerosols. Use in a well-ventilated area. Keep away from sources of ignition. Avoid prolonged or repeated exposure.
To Top