Aminopterin

SKU
A-2535
  • CAS:54-62-6
  • Formula:C19 H20 N8 O5
  • MW:440.418
  • Appearance:Solid
Product Name Qty
Aminopterin
50 mg
$96.82
Dihydrofolate reductase inhibitor; blocks nucleotide synthesis
More Information
SKU
A-2535
CAS #
54-62-6
Chemical Name
N-[4-[[(2,4-DIAMINO-6-PTERIDINYL)METHYL]AMINO]BENZOYL]-L-GLUTAMIC ACID
Chemical Formula
C19 H20 N8 O5
Molecular Weight
440.418
Appearance
Solid
Solubility
Soluble in water (partly), 0.1N NaOH, DMSO, NH4OH 2M (49.00 - 51.00 mg/ml), and ethanol 
Melting Point
225 °C
Storage Temp
Room Temp
THERAPEUTIC AREA
Oncological Disorders
USE
Aminopterin is a folic acid antagonist. Potent DHFR (dihydrofolate reductase) inhibitor.
MDL NUMBER
MFCD00036692
CHEMACX
X1006304-8
INCHI
InChI=1S/C19H20N8O5/c20-15-14-16(27-19(21)26-15)23-8-11(24-14)7-22-10-3-1-9(2-4-10)17(30)25-12(18(31)32)5-6-13(28)29/h1-4,8,12,22H,5-7H2,(H,25,30)(H,28,29)(H,31,32)(H4,20,21,23,26,27)
Peptide sequence
c1cc(ccc1C(=O)NC(CCC(=O)O)C(=O)O)NCc2cnc3c(n2)c(nc(n3)N)N
RTECS
MA1050000
UN #'S
UN 2811
HAZARD CLASS
Class 6.1
UN #'S UN 2811
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