- MW:298.3 Da
- Appearance:Crystalline solid
Amlexanox improves obesity-related metabolic dysfunction in mouse models. It increases thermogenesis and weight loss, decreases steatosis and improves insulin sensitivity. Inhibits TANK-binding kinase 1(TBK1) and IKKԑ (IC50=1.2 µM)².
Clinically useful in treatment of aphthus ulsers.
Amlexanox induces the complete and reversible non-apoptotic inhibition of cell migration and proliferation, and although amlexanox does not induce either the down-regulation of F-actin levels or the depolymerization of actin filaments, it does induce the tyrosine phosphorylation of cortactin, a Src substrate known to regulate actin bundling.
|Handling||Avoid breathing dust/fume/gas/mist/vapours/spray. Avoid prolonged or repeated exposure.|