Amlexanox

SKU
A-2431
  • CAS:68302-57-8
  • Formula:C16H14N2O4
  • MW:298.3 Da
  • Appearance:Crystalline solid
  • Purity:≥98%

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Product Name Qty
Amlexanox
50 mg
$337.16
Amlexanox
10 mg
$79.74

Description

Amlexanox improves obesity-related metabolic dysfunction in mouse models. It increases thermogenesis and weight loss, decreases steatosis and improves insulin sensitivity. Inhibits TANK-binding kinase 1(TBK1) and IKKԑ (IC50=1.2 µM)². 
Clinically useful in treatment of aphthus ulsers.

Amlexanox induces the complete and reversible non-apoptotic inhibition of cell migration and proliferation, and although amlexanox does not induce either the down-regulation of F-actin levels or the depolymerization of actin filaments, it does induce the tyrosine phosphorylation of cortactin, a Src substrate known to regulate actin bundling.

 

Product References
1. L Koch Nat. Rev. Endocrinol. 2013 9:185
2. SM Reilly et al. Nat. Med. 2012 19:313
3. L Matteo et al. J.Biol.Chem 2000 275:32573
More Information
Alternate Name/Synonyms
Amoxanox; AA-673; CHX-3673; Aphthasol; Elics; Solfa; Amlexanoxum
SKU
A-2431
CAS #
68302-57-8
Chemical Name
2-Amino-7-(1-methylethyl)-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylic Acid
Chemical Formula
C16H14N2O4
Molecular Weight
298.3 Da
Appearance
Crystalline solid
Purity
≥98%
Solubility
Soluble in organic solvents such as DMSO and dimethyl formamide (DMF).
Storage Temp
-20⁰C
THERAPEUTIC AREA
Not Available
USE
For research use only, not for human or veterinary use.
Handling
Avoid breathing dust/fume/gas/mist/vapours/spray. Avoid prolonged or repeated exposure.
GHS PICTOGRAMS
Handling Avoid breathing dust/fume/gas/mist/vapours/spray. Avoid prolonged or repeated exposure.
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