Amlodipine

SKU
A-2537
  • CAS:88150-42-9
  • Formula:C20H25ClN2O5
  • MW:408.9 Da
  • Appearance:Off-white powder
  • Purity:≥98%

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Product Name Qty
Amlodipine
1 g
$124.99
Amlodipine
5 g
$355.00
Amlodipine
100 mg
$39.99
Amlodipine
500 mg
$69.99

Description

Amlodipine is a calcium channel blocker with a demonstrated affinity for cellular membranes. When administered, it inhibits calcium influx in vascular muscle tissues. While it is classified as a dihydropyridine calcium blocker, there is evidence to suggest that amlodipine acts on dihydropyridine and nondihydropyridine sites alike.

Applications

In clinical medical practice, amlodipine is widely prescribed as an antihypertensive drug. As a calcium channel blocker, amlodipine has the effect of dilating arteries, thus allowing for less constricted blood flow. This compound may also be prescribed as a preventative drug for attacks of angina-related chest pain. Clinical trials have also investigated the effect of amlodipine on microvascular function. In more recent research, amlodipine has been paired with other calcium channel blockers in experimental two-drug combinations. Pairings of amlodipine with perindopril and hydrochlorothiazide have both been shown to be effective in significantly reducing blood pressure in sub-Saharan African populations.

 

More Information
Alternate Name/Synonyms
Amlodis; Amlodipino; Amlodipinum; Amlor; Amlocard; Intervask; Pelmec; Norvasc; Coroval; Amvaz; Lipinox; Caduet; Istin
SKU
A-2537
CAS #
88150-42-9
Chemical Name
3-O-ethyl 5-O-methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
Chemical Formula
C20H25ClN2O5
Molecular Weight
408.9 Da
Appearance
Off-white powder
Purity
≥98%
Solubility
Soluble in DMSO (25 mg/mL), ethanol (25 mg/mL), water (75.3 mg/mL), DMF (25 mg/mL), acetone, chloroform, ethyl acetate, and methanol.
Storage Temp
Room temperature
THERAPEUTIC AREA
Cardiological disorders
USE
Amlodipine is a dihydropyridine, calcium-channel blocking agent which is used to manage hypertension and coronary artery disease. It can be used as either monotherapy or combination therapy. Amlodipine along with other calcium channel blockers may protect stroke than any other classes of blood pressure-controlling drugs. Calcium channel blockers are considered to be the first choice of Raynaud's phenomenon.
MDL NUMBER
MFCD00864687
CHEMACX
X1402505-7
INCHI
InChI=1S/C20H25ClN2O5/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21/h5-8,17,23H,4,9-11,22H2,1-3H3
SMILES
CCOC(=O)C1=C(NC(=C(C1c2ccccc2Cl)C(=O)OC)C)COCCN
RTECS
US7968329
Handling
Danger! Toxic if swallowed. Causes serious eye damage, may cause damage to organs through prolonged or repeated exposure. Wear protective gloves/protective clothing/eye protection/face protection. Wash face, hands and any exposed skin thoroughly after handling.
Certificate of Analysis 1
GHS PICTOGRAMS
Handling Danger! Toxic if swallowed. Causes serious eye damage, may cause damage to organs through prolonged or repeated exposure. Wear protective gloves/protective clothing/eye protection/face protection. Wash face, hands and any exposed skin thoroughly after handling.
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