Antimycin A Complex
SKU
A-1268
- CAS:1397-94-0
- Formula:C28H40N2O9 (for A1)
- MW:548.6 Da
- Appearance:White crystals
- Purity:>95% by HPLC
SDS
CofA
Description
Induces apoptosis, which is not prevented by the presence of bcl-2. Inhibits mitochondrial electron transport specifically between cytochromes b and c1.
Antimycin A is a complex of related macrocyclic lactones, predominantly A1 to A4, isolated from several species of Streptomyces, first reported in the early 1950s for potent antifungal activity. There are over 20 known analogues in the antimycin A class, mostly involving variation of the fatty acid ester chain length or adjacent alkyl starting unit. Antimycin A binds to cytochrome C reductase at the Qi site, inhibiting the oxidation of ubiquinol to ubiquinone. Antimycin A is widely used as a bioprobe of respiration and other applications with over 5,000 literature citations.
More Information
Alternate Name/Synonyms
Antimycin A; Antimycin A1b; Antipiricullin; Fintrol; Virosin; Levoristatin; Vulgarin
SKU
A-1268
CAS #
1397-94-0
Chemical Name
[(2R,3S,6S,7R,8R)-3-[(3-formamido-2-hydroxybenzoyl)amino]-8-hexyl-2,6-dimethyl-4,9-dioxo-1,5-dioxonan-7-yl] 3-methylbutanoate
Chemical Formula
C28H40N2O9 (for A1)
Molecular Weight
548.6 Da
Appearance
White crystals
Purity
>95% by HPLC
Solubility
Ethanol: Clear colorless solution at 50 mg/mL
Melting Point
138-141°C
Preparation
N/A
Storage Temp
-20°C
RTECS
N/A
Handling
Avoid contact with skin, eyes or clothing. Use personal protective equipment as required. Wash contaminated clothing before reuse. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this product. Handle in accordance with good industrial hygiene and safety practice. Corrosive hazard. Wear protective gloves/clothing and eye/face protection.
Certificate of Analysis 1
Certificate of Analysis 2
Certificate of Analysis 3
| GHS PICTOGRAMS |
|
|---|---|
| Handling | Avoid contact with skin, eyes or clothing. Use personal protective equipment as required. Wash contaminated clothing before reuse. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this product. Handle in accordance with good industrial hygiene and safety practice. Corrosive hazard. Wear protective gloves/clothing and eye/face protection. |
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