Source: Rabbit. Immunogen: Synthetic peptide corresponding to aa 201-216 of human Bcl-X. Specificity: Recognizes human, mouse, rat Bcl-XL (strongly) and Bcl-XS (moderately). Application: IHC (FS, PS), WB.

Bcl-2 and Bcl-XL are anti-apoptotic paralogues that inhibit apoptosis elicited by a wide variety of stimuli, and play critical roles in cancer development and resistance to treatment. Many clinical studies have indicated that expression of these anti-apoptotic proteins in tumours is associated with poor prognosis. It has therefore been assumed that in cells the essential difference between Bcl-2 and Bcl-XL involves regulation of expression and that they are otherwise functionally similar.

Attached are a few published references from researchers who have used our Antiserum product. We respectfully thank them for their trust in our product. Inquire for a full reference list.

• NEUROSCIENCE:  Bcl-xL induces Drp1-dependent synapse formation in cultured hippocampal neurons, Hongmei Li, Yingbei Chen, Adrienne F. Jones, et al., PNAS, Feb 2008; 105: 2169 - 2174.

•  

  CELLULAR/MOLECULAR:  Zinc-Dependent Multi-Conductance Channel Activity in Mitochondria Isolated from Ischemic Brain, Laura Bonanni, Mushtaque Chachar, Teresa Jover-Mengual, et al., J. Neurosci., Jun 2006; 26: 6851 - 6862.