Aphidicolin

SKU

A-1026

CAS:38966-21-1
Formula:C₂₀H₃₄O₄
MW:338.5 Da
Appearance:White Powder
Purity:>99% (TLC)

SDS

CofA

Product Name	Qty
(+)-Aphidicolin Nigrospora oryzae 1 mg $95.66
(+)-Aphidicolin Nigrospora oryzae 5 mg $355.69
(+)-Aphidicolin, Nigrospora oryzae 25 mg $1,379.14

Details

Aphidicolin is a reversible Inhibitor of eukaryotic nuclear DNA replication. cell cycle at early S-phase.N K-independent Activation of c-Jun during Neuronal Apoptosis Induced by Multiple DNA-damaging Agents. DNA AND CHROMOSOMES: Cohesin Acetylation Promotes Sister Chromatid Cohesion Only in Association with the Replication Machinery. CELL BIOLOGY: RET Modulates Cell Adhesion via its Cleavage by Caspase in Sympathetic Neurons.

Isolated from Nigrospora oryzae

Low dose aphidicolin is an inhibitor of the DNA replicative polymerases α , δ, and ε¹. Aphidicolin is a potent and specific inhibitor of B-family DNA polymerases².

1.) http://www.jbc.org/content/290/48/28953.full.pdf+html

2.) http://nar.oxfordjournals.org/content/42/22/14013.full.pdf

Reviews

Safety

GHS PICTOGRAMS
Handling	Warning.Toxic. Potential Carcinogenic. Do not use this compound if you are not fully trained or are unaware of the hazards involved. Wear gloves/mask when handling product. Avoid contact by all means of exposure. Avoid contact with skin, eyes or clothing. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this product. Use with local exhaust ventilation.
UN #'S	Not Applicable
Packing Group	Not Applicable

Citations

Citations	Análisis de la señalización por Ret: caracterización de la cascada molecular B-Raf/IKKS y regulación de Ret por Sprouty1
	A balance between elongation and trimming regulates telomere stability in stem cells
	Arabidopsis POT1 associates with the telomerase RNP and is required for telomere maintenance
	Sororin cooperates with the acetyltransferase Eco2 to ensure DNA replication-dependent sister chromatid cohesion
	Early and late steps in telomere overhang processing in normal human cells: the position of the final RNA primer drives telomere shortening
	Endoplasmic reticulum stress-induced apoptosis requires bax for commitment and Apaf-1 for execution in primary neurons
	Cytosine arabinoside rapidly activates Bax-dependent apoptosis and a delayed Bax-independent death pathway in sympathetic neurons
	The limited role of NH2-terminal c-Jun phosphorylation in neuronal apoptosis: identification of the nuclear pore complex as a potential target of the JNK pathway
	Secreted herpes simplex virus-2 glycoprotein G modifies NGF-TrkA signaling to attract free nerve endings to the site of infection
	Inhibition of the c-Jun N-terminal kinase signaling pathway by the mixed lineage kinase inhibitor CEP-1347 (KT7515) preserves metabolism and growth of trophic factor-deprived neurons
	Secreted herpes simplex virus-2 glycoprotein G alters thermal pain sensitivity by modifying NGF effects on TRPV1
	Exposure to the polybrominated diphenyl ether mixture DE-71 damages the nigrostriatal dopamine system: role of dopamine handling in neurotoxicity
	Cohesin acetylation promotes sister chromatid cohesion only in association with the replication machinery
	RET modulates cell adhesion via its cleavage by caspase in sympathetic neurons
	Human mismatch repair: reconstitution of a nick-directed bidirectional reaction
	JNK-independent activation of c-Jun during neuronal apoptosis induced by multiple DNA-damaging agents
	BH3-only Bcl-2 family members are coordinately regulated by the JNK pathway and require Bax to induce apoptosis in neurons
	The activation loop phosphorylation of protein kinase D is an early marker of neuronal DNA damage
	Identification of JNK-dependent and -independent components of cerebellar granule neuron apoptosis
	Mixed-lineage kinase inhibitors require the activation of Trk receptors to maintain long-term neuronal trophism and survival
	Formaldehyde-induced genome instability is suppressed by an XPF-dependent pathway
	Alterations to the circuitry of the frontal cortex following exposure to the polybrominated diphenyl ether mixture, DE-71
	Temporal differences in DNA replication during the S phase using single fiber analysis of normal human fibroblasts and glioblastoma T98G cells
	DNA replication in early S phase pauses near newly activated origins
	Developmental exposure to the organochlorine insecticide endosulfan damages the nigrostriatal dopamine system in male offspring
	Early development and axis specification in the sea anemone Nematostella vectensis
	Selective damage to dopaminergic transporters following exposure to the brominated flame retardant, HBCDD
	Developmental exposure to the organochlorine insecticide endosulfan alters expression of proteins associated with neurotransmission in the frontal cortex
	DNA damage checkpoint responses in the S phase of synchronized diploid human fibroblasts
	Alteration to Dopaminergic Synapses Following Exposure to Perfluorooctane Sulfonate (PFOS), in Vitro and in Vivo
	Herpes simplex virus glycoprotein G enhances chemotaxis through modi!cation of plasma membrane microdomains and receptor tra
	TrkA COOH-terminal tail: its relevance on receptor stability and signaling for cell differentiation and survival
	Defining Multiple Steps in Human Telomere End Processing
	Telomere -associated proteins in Arabidopsis thaliana
	Zellteilungsregulation meristematischer Wurzelzellen (Tabak BY-2) durch Phytohormone und Zucker
	Genetic analysis of the Replication Protein A large subunit family in Arabidopsis reveals unique and overlapping roles in DNA repair, meiosis and DNA replication
	Genetic and evolutionary analysis of plant replication protein A 1 (RPA1)
	Fragile X Mental Retardation Protein regulates R-loop formation and prevents global chromosome fragility