Aphidicolin
- CAS:38966-21-1
- Formula:C20H34O4
- MW:338.5 Da
- Appearance:White Powder
- Purity:>99% (TLC)

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Description
Aphidicolin is a reversible inhibitor of nuclear DNA replication in eukaryotes and some animal viruses. It interferes with dCTP-specific binding sites on DNA polymerase-α. It also works on other DNA polymerases, however it does not work on DNA polymerase-β.
Viruses inducing DNA polymerase-α, such as Herpes simplex, can be affected by aphidicolin because of its mechanism. It could be used for clinical study.
Isolated from Nigrospora oryzae.
Applications
• Control of cell proliferation
• DNA pol-β studies
• Read More: Pathology Research Using Mitophagy Modulators
References
• “Aphidicolin: a specific inhibitor of nuclear DNA replication in eukaryotes”
• “Effect of aphidicolin on viral and human DNA polymerases”
• "DNA Replication Dynamics of the GGGGCC Repeat of the C9orf72 Gene"
• "Structural basis for inhibition of DNA replication by aphidicolin"
GHS PICTOGRAMS | ![]() |
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Handling | Warning.Toxic. Potential Carcinogenic. Do not use this compound if you are not fully trained or are unaware of the hazards involved. Wear gloves/mask when handling product. Avoid contact by all means of exposure. Avoid contact with skin, eyes or clothing. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this product. Use with local exhaust ventilation. |
UN #'S | Not Applicable |
Packing Group | Not Applicable |