Aphidicolin
SKU
A-1026
- CAS:38966-21-1
- Formula:C20H34O4
- MW:338.5 Da
- Appearance:White Powder
- Purity:>99% (TLC)
SDS
CofA
Aphidicolin is a reversible Inhibitor of eukaryotic nuclear DNA replication. cell cycle at early S-phase.N K-independent Activation of c-Jun during Neuronal Apoptosis Induced by Multiple DNA-damaging Agents. DNA AND CHROMOSOMES: Cohesin Acetylation Promotes Sister Chromatid Cohesion Only in Association with the Replication Machinery. CELL BIOLOGY: RET Modulates Cell Adhesion via its Cleavage by Caspase in Sympathetic Neurons.
Isolated from Nigrospora oryzae
Low dose aphidicolin is an inhibitor of the DNA replicative polymerases α , δ, and ε1. Aphidicolin is a potent and specific inhibitor of B-family DNA polymerases2.
1.) http://www.jbc.org/content/290/48/28953.full.pdf+html
2.) http://nar.oxfordjournals.org/content/42/22/14013.full.pdf
More Information
Alternate Name/Synonyms
APC; ICI 69653; NSC 234714
SKU
A-1026
CAS #
38966-21-1
Chemical Name
(1S,2S,5R,6R,7R,10S,12R,13R)-6,13-bis(hydroxymethyl)-2,6-dimethyltetracyclo[10.3.1.01,10.02,7]hexadecane-5,13-diol
Chemical Formula
C20H34O4
Molecular Weight
338.5 Da
Appearance
White Powder
Purity
>99% (TLC)
Solubility
Methanol: Clear colorless solution at 10 mg/ml
Melting Point
230°C
Preparation
N/A
Storage Temp
+4°C
THERAPEUTIC AREA
Not Available
USE
For research use only. Not intended for diagnostic or therapeutic use. Aphidicolin is a tetracyclic diterpene with antibiotic, antiviral and antimitotic properties by blocking the cell cycle at early S-phase. This property has been used to synchronise cell division and is useful as a tool in cell differentiation research. Aphidicolin induces apoptosis, prolongs the half-life of DNA methyltransferase, is active against Leishmania parasites and acts synergistically with the antitumor agents, vincristine and doxorubicin.
Merck Index
Merck Index: 13.734.2001
MDL NUMBER
MFCD00083214
CHEMACX
X1001937-7
INCHI
InChI=1S/C20H34O4/c1-17(11-21)15-4-3-13-9-14-10-19(13,7-8-20(14,24)12-22)18(15,2)6-5-16(17)23/h13-16,21-24H,3-12H2,1-2H3/t13-,14+,15-,16+,17-,18-,19-,20-/m0/s1
SMILES
C[C@]12CC[C@H]([C@@]([C@@H]1CC[C@@H]3[C@@]24CC[C@@]([C@H](C3)C4)(CO)O)(C)CO)O
Peptide sequence
Not Applicable
RTECS
PB9185000
UN #'S
Not Applicable
PACKING GROUP
Not Applicable
HAZARD CLASS
Not Applicable
Handling
Warning.Toxic. Potential Carcinogenic. Do not use this compound if you are not fully trained or are unaware of the hazards involved. Wear gloves/mask when handling product. Avoid contact by all means of exposure. Avoid contact with skin, eyes or clothing. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this product. Use with local exhaust ventilation.
Citations
CELL BIOLOGY:
Sororin cooperates with the acetyltransferase Eco2 to ensure DNA replication-dependent sister chromatid cohesion
Andrea L. Lafont, Jianhua Song, and Susannah Rankin
PNAS, Nov 2010; 107: 20364 - 20369.
Citations_Hyperlink
http://www.pnas.org/cgi/reprint/107/47/20364
Certificate of Analysis 1
Certificate of Analysis 2
Certificate of Analysis 3
| GHS PICTOGRAMS |
|
|---|---|
| Handling | Warning.Toxic. Potential Carcinogenic. Do not use this compound if you are not fully trained or are unaware of the hazards involved. Wear gloves/mask when handling product. Avoid contact by all means of exposure. Avoid contact with skin, eyes or clothing. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this product. Use with local exhaust ventilation. |
| UN #'S | Not Applicable |
| Packing Group | Not Applicable |