Apicidin is a novel fungal metabolite that is a potent chemotherapeutic and anti-protozoal agent, exhibiting anti-histone deacetylase activity.
It inhibits cell proliferation and antitumor effects in several human cancer cell lines by inducing apoptosis via Fas/Fas ligand. The metabolite arrests the cell cycle at the G1 phase and induces p21 and gelsolin, therefore, it has shown a potential antiproliferative property.
It is used for treatment of parasites in vitro due to its target, histone deacetylase. The acetylation and deacetylation of histones are considered essential in gene expression and it has been proven that histone deacetylation inhibitors have antiparasitic effects.
• Chemotherapeutic agent
• Antiprotozoal agent
• Used as an inhibitor of histone deacetylation
Not for human therapeutic use or for medicinal purposes. For research applications only.
|Handling||Warning. Very Toxic. Store in tightly sealed vial.|
|UN #'S||UN 2811|