Apicidin

SKU
A-1264
  • CAS:183506-66-3
  • Formula:C34H49N5O6
  • MW:623.8
  • Appearance:White powder
  • Purity:≥95% by HPLC

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Product Name Qty
Apicidin
1 mg
$61.16
Apicidin
5 mg
$242.16

Description

Apicidin is a novel fungal metabolite that is a potent chemotherapeutic and anti-protozoal agent, exhibiting anti-histone deacetylase activity.

It inhibits cell proliferation and antitumor effects in several human cancer cell lines by inducing apoptosis via Fas/Fas ligand. The metabolite arrests the cell cycle at the G1 phase and induces p21 and gelsolin, therefore, it has shown a potential antiproliferative property.

It is used for treatment of parasites in vitro due to its target, histone deacetylase. The acetylation and deacetylation of histones are considered essential in gene expression and it has been proven that histone deacetylation inhibitors have antiparasitic effects.

 

Applications

• Chemotherapeutic agent

• Antiprotozoal agent

• Used as an inhibitor of histone deacetylation

 

References

• “Apicidin: A novel antiprotozoal agent that inhibits parasite histone deacetylase”

• “Apicidin, a Histone Deacetylase Inhibitor, Inhibits Proliferation of Tumor Cells via Induction of p21WAF1/Cip1 and Gelsolin”

• “Apicidin, a Histone Deacetylase Inhibitor, Induces Apoptosis and Fas/Fas Ligand Expression in Human Acute Promyelocytic Leukemia Cells”

• “Apicidin is a histone deacetylase inhibitor with anti-invasive and anti-angiogenic potentials”

 

Not for human therapeutic use or for medicinal purposes. For research applications only.

More Information
Alternate Name/Synonyms
cyclo-L-(2-Amino-8-oxodecanoyl)-L-(N-methoxy-tryptophan)-L-isoleucyl-D-pipecolinyl; CHEMBL430060; OSI-2040
SKU
A-1264
CAS #
183506-66-3
Chemical Name
cyclo-L-(2-Amino-8-oxodecanoyl)-L-(N-methoxy-tryptophan)-L-isoleucyl-D-pipecolinyl
Chemical Formula
C34H49N5O6
Molecular Weight
623.8
Appearance
White powder
Purity
≥95% by HPLC
Solubility
Soluble in ETOH, DMSO (1mg/mL)
Melting Point
190°C
Storage Temp
-20°C
THERAPEUTIC AREA
Oncological Disorders
USE
A histone deacetylase (HDAC) inhibitor, cyclic peptide antibiotics, anti-angiogenic and an inducer of apoptosis.
MDL NUMBER
MFCD03452661
CHEMACX
X1430043-3
INCHI
InChI=1S/C33H47N5O6/c1-5-21(3)28-33(43)37-19-13-12-18-27(37)31(41)34-25(16-9-7-8-14-22(39)6-2)30(40)36-29(32(42)35-28)24-20-38(44-4)26-17-11-10-15-23(24)26/h10-11,15,17,20-21,25,27-29H,5-9,12-14,16,18-19H2,1-4H3,(H,34,41)(H,35,42)(H,36,40)/t21-,25+,27-,28+,29-/m1/s1
SMILES
CC[C@@H](C)[C@H]1C(=O)N2CCCC[C@@H]2C(=O)N[C@H](C(=O)N[C@@H](C(=O)N1)c3cn(c4c3cccc4)OC)CCCCCC(=O)CC
Peptide sequence
Not Applicable
UN #'S
UN 2811
PACKING GROUP
II
Handling
Warning. Very Toxic. Store in tightly sealed vial.
Certificate of Analysis 1
Certificate of Analysis 2
Handling Warning. Very Toxic. Store in tightly sealed vial.
UN #'S UN 2811
Packing Group II
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