Apigenin

SKU
A-1108
  • CAS:520-36-5
  • Formula:C15H10O5
  • MW:270.2
  • Appearance:Yellow to slightly brown powder
  • Purity:≥98%

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Product Name Qty
Apigenin
100 mg
$336.03
Apigenin
10 mg
$41.13
Apigenin
50 mg
$123.47
Apigenin
20 mg
$86.57

Description

Apigenin is an antioxidant flavonoid that has anti-inflammatory and antitumor properties.

It has been reported that apigenin suppresses various human cancers in vitro and in vivo by multiple biological effects, such as promoting apoptosis through activation of p53 and autophagy, arresting cell cycle, suppressing cell migration, and stimulating an immune response.

It has been demonstrated that apigenin induces the expression of antiangiogenic protein thrombospondin-1 (TSP1) via a mechanism driven by mRNA-binding protein HuR and has effect on carcinoma.

The flavonoid is a selective CK2 inhibitor. According to a study about murine pancreatic cancer, apigenin increased transcription factor Ikaros and affected maintenance of T cell homeostasis by regulating CK2.

In addition, apigenin has shown neuroprotective properties in a human model of neurodegenerative Alzheimer’s disease.

 

Applications

• Potential cancer chemopreventive agent in vivo and in vitro

• Used in study of neurodegenerative diseases

• Used in study of signaling pathway

 

References

• “Apigenin: A Promising Molecule for Cancer Prevention”

• “Apigenin in cancer therapy: anti-cancer effects and mechanisms of action”

• “Apigenin and cancer chemoprevention: Progress, potential and promise”

• “Role of Apigenin in Cancer Prevention via the Induction of Apoptosis and Autophagy”

• “Neuroprotective effects of apigenin against inflammation, neuronal excitability and apoptosis in an induced pluripotent stem cell model of Alzheimer’s disease”

• “Apigenin: Selective CK2 inhibitor increases Ikaros expression and improves T cell homeostasis and function in murine pancreatic cancer”

• “Apigenin inhibits STAT3/CD36 signaling axis and reduces visceral obesity”

 

Not for human therapeutic use or for medicinal purposes. For research applications only.

More Information
Alternate Name/Synonyms
4′,5,7-Trihydroxyflavone; 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one; Chamomile; Versulin
SKU
A-1108
CAS #
520-36-5
Chemical Name
4',5,7-Trihydroxyflavone
Chemical Formula
C15H10O5
Molecular Weight
270.2
Appearance
Yellow to slightly brown powder
Purity
≥98%
Solubility
Soluble in Water (50 mg/mL)
Melting Point
345-350°C
Storage Temp
Room temperature
THERAPEUTIC AREA
Candidate of cancer therapeutics
Certificate of Analysis 1
Certificate of Analysis 2
Certificate of Analysis 3
GHS PICTOGRAMS
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