- Appearance:Yellow to slightly brown powder
Apigenin is an antioxidant flavonoid that has anti-inflammatory and antitumor properties.
It has been reported that apigenin suppresses various human cancers in vitro and in vivo by multiple biological effects, such as promoting apoptosis through activation of p53 and autophagy, arresting cell cycle, suppressing cell migration, and stimulating an immune response.
It has been demonstrated that apigenin induces the expression of antiangiogenic protein thrombospondin-1 (TSP1) via a mechanism driven by mRNA-binding protein HuR and has effect on carcinoma.
The flavonoid is a selective CK2 inhibitor. According to a study about murine pancreatic cancer, apigenin increased transcription factor Ikaros and affected maintenance of T cell homeostasis by regulating CK2.
In addition, apigenin has shown neuroprotective properties in a human model of neurodegenerative Alzheimer’s disease.
• Potential cancer chemopreventive agent in vivo and in vitro
• Used in study of neurodegenerative diseases
• Used in study of signaling pathway
Not for human therapeutic use or for medicinal purposes. For research applications only.