Catehpsins belong to the papain superfamily of lysosomal cysteine proteases. The cathepsin inhibitor induces rapid apoptotic death in human cancer cell lines. Cathepsin S inhibitor induces autophagy and mitochondrial apoptosis in human glioblastoma cells. Cathepsin B and L inhibitors suppress normal lysosomal degradation and the processing of lysosomal enzyme, leading to lysosomal dysfunction. So it result in consequent cell death in pancreatic β–cells.
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