Granzymes (granule-secreted enzymes) are serine proteases that are released by cytoplasmic granules within cytotoxic T cells and natural killer (NK) cells. They trigger programmed cell death in the target cell. Its important role is to eliminate cells that have become cancerous or are infected with viruses or bacteria in the immune defense.

Granzyme B activates caspase (especially caspase-3) and also cleaves the factors like ICAD. It also cleaves many of the proteins lick Bid, which recruits the proteins Bax and Bak to change the membrane permeability of the mitochondria, causing the release of cytochrome c responsible for apoptosis in the absence of caspase activity. Granzyme A is also an abundant granzyme released by cytotoxic T cells and is important in cytotoxic T cell induced apoptosis, activating caspase independent pathways.

AG Scientific can ship FedEx directly to your lab, from small-scale to bulk orders. Our leadership in bulk supply allows us to provide custom product packaging and create multiple product forms. We offer “just in time” delivery, private labeling, and custom formulations for specific research needs.

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  1. Ac-ESMD-CHO
    Ac-ESMD-CHO
    G-1073

    Starting at $66.08

  2. Ac-IETD-AMC
    Ac-IETD-AMC
    G-1081

    Starting at $47.83

  3. Ac-IETD-CHO
    Ac-IETD-CHO
    G-1071

    Starting at $112.77

  4. Ac-IETD-pNA
    Ac-IETD-pNA
    G-1085

    Starting at $31.90

  5. EZSolution Q-VD-OPh
    EZSolution Q-VD-OPh
    E-2317

    Starting at $222.12

  6. EZSolution Q-VD-OPh, Negative Control
    EZSolution Q-VD-OPh, Negative Control
    E-2318

    Starting at $187.95

  7. MDL-12330A Hydrochloride
    MDL-12330A Hydrochloride
    M-1026

    Starting at $74.04

  8. Nafamostat Mesylate
    Nafamostat Mesylate
    F-1160

    Starting at $71.40

  9. Z-IE(OMe)TD(OMe)-FMK
    Z-IE(OMe)TD(OMe)-FMK
    G-1077

    Starting at $250.59

  10. Z-IETD-pNA
    Z-IETD-pNA
    G-1083

    Starting at $25.05

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