p53 is the tumor suppressor that regulates the expression of p53 upregulated modulator of apoptosis (PUMA). PUMA is involved in p53-dependent and –independent apoptosis induced by a variety of signals, and is regulated by transcription factors, not by post-translational modifications. P53 is a major orchestrator of the cellular response to a broad array of stress types by regulating apoptosis, cell cycle arrest, senescence, DNA repair and genetic stability. After activation, PUMA interacts with the multidomain Bcl-2 family members to signal apoptosis to the mitochondria by inducing outer membrane permeabilization.

AG Scientific can ship FedEx directly to your lab, from small-scale to bulk orders. Our leadership in bulk supply allows us to provide custom product packaging and create multiple product forms. We offer “just in time” delivery, private labeling, and custom formulations for specific research needs.

 

FREE REVIEW ARTICLES

  • p53 at a glanceColleen A. Brady and Laura D. Attardi. p53 at a glance. J. Cell Sci, 2010; 123: 2527 - 2532.

 

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  1. 17-AAG (Tanespimycin) chemical structure | Hsp 90 Inhibitor | Anti-tumor | AG Scientific, Inc.
    17-AAG
    A-1256

    Starting at $42.37

  2. CP-31398 Dihydrochloride
    CP-31398 Dihydrochloride
    C-2270

    Starting at $100.25

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