AR-A 014418

SKU
A-2498
  • CAS:487021-52-3
  • Formula:C12H12N4O4S
  • MW:308.31
  • Appearance:Off-White Solid
  • Purity:98% by TLC
Product Name Qty
AR-A 014418
5 mg
$148.07

Cell-permeable. A selective glycogen synthase kinase 3 (GSK-3) inhibitor (IC= 104 nM). Inhibition is competitive with respect to ATP (K = 38nM). Exhibits specificity for GSK-3 over cdk2 and cdk5 (ICvalues are 100M) and over 26 other kinases. Inhibitsamyloid-mediated neurodegeneration in hippocampal slices.

More Information
SKU
A-2498
CAS #
487021-52-3
Chemical Name
N-[(4-METHOXYPHENYL)METHYL]-N'-(5-NITRO-2-THIAZOLYL)UREA
Chemical Formula
C12H12N4O4S
Molecular Weight
308.31
Appearance
Off-White Solid
Purity
98% by TLC
Solubility
DMSO (30 mg/ml)
Melting Point
208-210 °C
Storage Temp
-20°C
THERAPEUTIC AREA
Psychological Disorders
USE
GSK-3 inhibitors useful for the treatment of bipolar disorder and depression.
MDL NUMBER
MFCD08277040
CHEMACX
X1533647-5
INCHI
InChI=1S/C12H12N4O4S/c1-20-9-4-2-8(3-5-9)6-13-11(17)15-12-14-7-10(21-12)16(18)19/h2-5,7H,6H2,1H3,(H2,13,14,15,17)
SMILES
COc1ccc(cc1)CNC(=O)Nc2ncc(s2)[N+](=O)[O-]
Handling
Protect from light and air
GHS PICTOGRAMS
HandlingProtect from light and air
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