KU-55933

SKU
A-2189
  • CAS:587871-26-9
  • Formula:C21H17NO3S2
  • MW:395.49
  • Appearance:White Solid
  • Purity:97% by HPLC

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Product Name Qty
KU-55933
5 mg
$187.95

A potent, selective and ATP-competitive inhibitor of ATM Kinase (K = 2.2 nM; IC= 13 nM). Inhibits DNA-PK, mTOR, PI 3-K, PI 4-K, and ATR at much higher concentrations (IC= 2500, 9300, 16600, 100000 and 100000 nM, respectively). KU-55933 inhibits cancer cell proliferation by inducing G(1) cell-cycle arrest. Sensitizes cells to ionizing radiations and chemotherapeutics. Induces apoptosis in breast and prostate cancer cell lines. 

More Information
Alternate Name/Synonyms
2-Morpholin-4-yl-6-thianthren-1-yl-pyran-4-one
SKU
A-2189
CAS #
587871-26-9
Chemical Name
2-(4-Morpholinyl)-6-(1-thianthrenyl)-4H-pyran-4-one
Chemical Formula
C21H17NO3S2
Molecular Weight
395.49
Appearance
White Solid
Purity
97% by HPLC
Solubility
DMSO (100 mM) and Ethanol (50 mM)
Storage Temp
-20°C
THERAPEUTIC AREA
Oncological Disorders
USE
A cell-permeable, potent, selective and ATP-competitive ATM inhibitor use in cancer
MDL NUMBER
MFCD08276985
CHEMACX
X1544046-5
INCHI
InChI=1S/C21H17NO3S2/c23-14-12-16(25-20(13-14)22-8-10-24-11-9-22)15-4-3-7-19-21(15)27-18-6-2-1-5-17(18)26-19/h1-7,12-13H,8-11H2
SMILES
c1ccc2c(c1)Sc3cccc(c3S2)c4cc(=O)cc(o4)N5CCOCC5
Handling
Protect from air and light
Handling Protect from air and light
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