Aurora Kinase B Inhibitor (AZD1152-HQPA)

SKU
A-2192
  • CAS:722544-51-6
  • Formula:C26H30FN7O3
  • MW:507.56
  • Appearance:Crystalline Solid
  • Purity:99% by HPLC
Product Name Qty
Aurora Kinase B Inhibitor (AZD1152-HQPA)
5 mg
$222.12
Aurora Kinase B Inhibitor (AZD1152-HQPA)
25 mg
$654.97

A potent and specific Aurora kinase B inhibitor. It is 1000-fold more selective for aurora kinase B than for aurora kinase A ( Ki values of 1300 nM and 0.36 nM for aurora kinase A and B, respectively). At concentrations as low as 0.01 M, AZD 1152 produced a significant (p<0.05) decrease in the ability of NB4 cells to proliferate by 48 hours.

More Information
Alternate Name/Synonyms
AZD1152-HQPA
SKU
A-2192
CAS #
722544-51-6
Chemical Name
3-[[7-[3-[ETHYL(2-HYDROXYETHYL)AMINO]PROPOXY]-4-QUINAZOLINYL]AMINO]-N-(3-FLUOROPHENYL)-1H-PYRAZOLE-5-ACETAMIDE
Chemical Formula
C26H30FN7O3
Molecular Weight
507.56
Appearance
Crystalline Solid
Purity
99% by HPLC
Solubility
DMSO
Stability
N/A
Storage Temp
-20°C
THERAPEUTIC AREA
Oncological Disorders
USE
A potent and specific Aurora kinase B inhibitor use in pancreatic and colon cancer
MDL NUMBER
MFCD10687152
CHEMACX
X1812315-4
INCHI
InChI=1S/C26H30FN7O3/c1-2-34(10-11-35)9-4-12-37-21-7-8-22-23(16-21)28-17-29-26(22)31-24-14-20(32-33-24)15-25(36)30-19-6-3-5-18(27)13-19/h3,5-8,13-14,16-17,35H,2,4,9-12,15H2,1H3,(H,30,36)(H2,28,29,31,32,33)
SMILES
CCN(CCCOc1ccc2c(c1)ncnc2Nc3cc([nH]n3)CC(=O)Nc4cccc(c4)F)CCO
Peptide sequence
Not Applicable
RTECS
Not Applicable
UN #'S
Not Applicable
PACKING GROUP
Not Applicable
HAZARD CLASS
Not Applicable
Handling
Protect from light and moisture
Promo text for AGS discount
N/A
GHS PICTOGRAMS
Handling Protect from light and moisture
UN #'S Not Applicable
Packing Group Not Applicable
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