Bafilomycin A1

SKU

B-1183

CAS:88899-55-2
Formula:C₃₅H₅₈O₉
MW:622.8 Da
Appearance:White solid
Purity:>95% by HPLC

SDS

CofA

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Product Name	Qty
Bafilomycin A1 inquire $0.00

Details

A macrolide antibiotic that acts as a specific inhibitor of vacuolar-type H+-ATPase. Useful in distinguishing among different types of ATPases. Endothelin-converting enzyme 1 degrades neuropeptides in endosomes to control receptor recycling. Post-endocytic sorting of calcitonin Receptor-like Receptor and Receptor Activity-Modifying Protein 1. Additionally, Bafilomycin A1 prevents lysosomal cholesterol trafficking in macrophages and can be used to distinguish different types of ATPases. Research shows that Bafilomycin A1 can inhibit macroautophagy and promote apoptosis in colon cancer cells.

Specifications

More Information

Alternate Name/Synonyms

Baf-A1; Baf A; Hygrolidin; tetraen-2-one

SKU

B-1183

CAS #

88899-55-2

Chemical Name

(3Z,5E,7R,8S,9S,11E,13E,15S,16R)-16-[(2S,3R,4S)-4-[(2R,4R,5S,6R)-2,4-dihydroxy-5-methyl-6-propan-2-yloxan-2-yl]-3-hydroxypentan-2-yl]-8-hydroxy-3,15-dimethoxy-5,7,9,11-tetramethyl-1-oxacyclohexadeca-3,5,11,13-tetraen-2-one

Chemical Formula

C₃₅H₅₈O₉

Molecular Weight

622.8 Da

Appearance

White solid

Purity

>95% by HPLC

Solubility

Soluble in ethanol, methanol, DMF or DMSO. DMSO @ 50mg/ml. Poor water solubility.

Melting Point

N/A

Preparation

N/A

Storage Temp

-20°C

THERAPEUTIC AREA

Oncological Disorders

USE

Bafilomycin A1 inhibit macroautophagy and promote apoptosis in colon cancer cells. Baf A1 inhibits the action of Tentanus toxin in spinal cord neurons in cell culture. It also inhibits rhinovirus infection in human airways.

Merck Index

N/A

MDL NUMBER

MFCD06795130

CHEMACX

X1087211-6

INCHI

InChI=1S/C35H58O9/c1-19(2)32-24(7)27(36)18-35(40,44-32)26(9)31(38)25(8)33-28(41-10)14-12-13-20(3)15-22(5)30(37)23(6)16-21(4)17-29(42-11)34(39)43-33/h12-14,16-17,19,22-28,30-33,36-38,40H,15,18H2,1-11H3/b14-12+,20-13+,21-16+,29-17-/t22-,23+,24-,25-,26-,27+,28-,30-,31+,32+,33+,35+/m0/s1

SMILES

C[C@H]1C/C(=C/C=C/[C@@H]([C@H](OC(=O)/C(=C/C(=C/[C@H]([C@H]1O)C)/C)/OC)[C@@H](C)[C@H]([C@H](C)[C@]2(C[C@H]([C@@H]([C@H](O2)C(C)C)C)O)O)O)OC)/C

Peptide sequence

Not Applicable

RTECS

Not Applicable

UN #'S

Not Applicable

PACKING GROUP

Not Applicable

HAZARD CLASS

Not Applicable

Handling

Warning; Toxic. May be Carcinogenic. Ensure adequate ventilation, especially in confined areas. Use personal protective equipment as required. Use with local exhaust ventilation. Do not breathe dust/fume/gas/mist/vapors/spray.

Key Words

Bafilomycin A1 , Mitochondrial uncoupling, neuronal cells, V-ATPase

msds 1

B-1183, BAFILOMYCIN A1, SDS, diamond format.pdf

Certificate of Analysis 1

B-1183, G1205B.pdf

Certificate of Analysis 2

B-1183, G1205A.pdf

Certificate of Analysis 3

B-1183, G1205.pdf

Reviews

Safety

GHS PICTOGRAMS
Handling	Warning; Toxic. May be Carcinogenic. Ensure adequate ventilation, especially in confined areas. Use personal protective equipment as required. Use with local exhaust ventilation. Do not breathe dust/fume/gas/mist/vapors/spray.
UN #'S	Not Applicable
Packing Group	Not Applicable

Citations

Citations	Brucella intracellular replication requires trafficking through the late endosomal/lysosomal compartment
	Stimulation of Synaptic Vesicle Exocytosis by the Mental Disease Gene DISC1 is Mediated by N-Type Voltage-Gated Calcium Channels
	Autophagy regulates lipolysis and cell survival through lipid droplet degradation in androgen-sensitive prostate cancer cells
	Dectin-1 activation controls maturation of β-1,3-glucan-containing phagosomes
	Regulation of Alpha-synuclein Accumulation by the Autophagy-lysosome Pathway in a Preclinical Model of Parkinson Disease
	Autophagy Signaling in Prostate Cancer: Identification of a Novel Phosphatase
	WLS-dependent secretion of WNT3A requires Ser209 acylation and vacuolar acidification
	Tonic NMDA receptor-mediated current in prefrontal cortical pyramidal cells and fast-spiking interneurons
	Membrane Serine Protease Protects Mycobacterium Avium Subsp. Paratuberculosis against Phagosomal Acid Stress
	RECONNOITERING WNTLESS IN THE WNT SECRETION PATHWAY
	IFN-β mediates suppression of IL-12p40 in human dendritic cells following infection with virulent Francisella tularensis
	The HPV16 and MusPV1 papillomaviruses initially interact with distinct host components on the basement membrane
	Energizing an invertebrate embryo: bafilomycin-dependent respiration and the metabolic cost of proton pumping by the V-ATPase
	Selective clearance of aberrant tau proteins and rescue of neurotoxicity by transcription factor EB
	Development of potent autophagy inhibitors that sensitize oncogenic BRAF V600E mutant melanoma tumor cells to vemurafenib
	Computational model for autophagic vesicle dynamics in single cells
	Cytosolic clearance of replication-deficient mutants reveals Francisella tularensis interactions with the autophagic pathway
	Lysosomes shape Ins(1,4,5)P3-evoked Ca2+ signals by selectively sequestering Ca2+ released from the endoplasmic reticulum
	Post-endocytic sorting of calcitonin receptor-like receptor and receptor activity-modifying protein 1
	V-ATPase inhibition prevents recovery from anoxia in Artemia franciscana embryos: quiescence signaling through dissipation of proton gradients
	PI3K-C2α knockdown decreases autophagy and maturation of endocytic vesicles
	Rapid recycling of Ca2+ between IP3-sensitive stores and lysosomes
	BNIP3 regulates AT101 [(-)-gossypol] induced death in malignant peripheral nerve sheath tumor cells
	ATP6V0C knockdown in neuroblastoma cells alters autophagy-lysosome pathway function and metabolism of proteins that accumulate in neurodegenerative disease
	The C-terminal sequence of RhoB directs protein degradation through an endo-lysosomal pathway
	Fluorescence methods for analysis of interactions between Ca(2+) signaling, lysosomes, and endoplasmic reticulum
	PI3K-C2α: Insights into Autophagy and Endocytosis
	Tamoxifen Induces Cytotoxic Autophagy in Glioblastoma
	Functions of autophagy in lipid homeostasis and survival in androgen-dependent prostate cancer cells
	The pan erbB inhibitor PD168393 enhances lysosomal dysfunction-induced apoptotic death in malignant peripheral nerve sheath tumor cells
	Dectin-1 Controls TLR9 Trafficking to Phagosomes Containing β-1,3 Glucan
	Mechanisms of AT101 [(-)-gossypol] induced cytotoxicity in malignant peripheral nerve sheath tumors
	Concurrent Autophagy Inhibition Overcomes the Resistance of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Human Bladder Cancer Cells
	RACK1 depletion in the ribosome induces selective translation for non-canonical autophagy
	The AMPK stress response pathway mediates anoikis resistance through inhibition of mTOR and suppression of protein synthesis
	The Francisella O-antigen mediates survival in the macrophage cytosol via autophagy avoidance
	The tetraspanin CD82 is specifically recruited to fungal and bacterial phagosomes prior to acidification
	V-ATPase expression during development of Artemia franciscana embryos: potential role for proton gradients in anoxia signaling
	The PINK1 kinase-driven ubiquitin ligase Parkin promotes mitochondrial protein import through the presequence pathway in living cells
	Replication of Coxiella burnetii in a lysosome-like vacuole does not require lysosomal hydrolases

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