A macrolide antibiotic that acts as a specific inhibitor of vacuolar-type H+-ATPase. Useful in distinguishing among different types of ATPases. Endothelin-converting enzyme 1 degrades neuropeptides in endosomes to control receptor recycling. Post-endocytic sorting of calcitonin Receptor-like Receptor and Receptor Activity-Modifying Protein 1. Additionally, Bafilomycin A1 prevents lysosomal cholesterol trafficking in macrophages and can be used to distinguish different types of ATPases. Research shows that Bafilomycin A1 can inhibit macroautophagy and promote apoptosis in colon cancer cells.
|Handling||Warning; Toxic. May be Carcinogenic. Ensure adequate ventilation, especially in confined areas. Use personal protective equipment as required. Use with local exhaust ventilation. Do not breathe dust/fume/gas/mist/vapors/spray.|
|UN #'S||Not Applicable|
|Packing Group||Not Applicable|