
A macrolide antibiotic that acts as a specific inhibitor of vacuolar-type H+-ATPase. Useful in distinguishing among different types of ATPases. Endothelin-converting enzyme 1 degrades neuropeptides in endosomes to control receptor recycling. Post-endocytic sorting of calcitonin Receptor-like Receptor and Receptor Activity-Modifying Protein 1. Additionally, Bafilomycin A1 prevents lysosomal cholesterol trafficking in macrophages and can be used to distinguish different types of ATPases. Research shows that Bafilomycin A1 can inhibit macroautophagy and promote apoptosis in colon cancer cells.
More Information
Alternate Name/Synonyms
Baf-A1; Baf A; Hygrolidin; tetraen-2-one
SKU
B-1183
CAS #
88899-55-2
Chemical Name
(3Z,5E,7R,8S,9S,11E,13E,15S,16R)-16-[(2S,3R,4S)-4-[(2R,4R,5S,6R)-2,4-dihydroxy-5-methyl-6-propan-2-yloxan-2-yl]-3-hydroxypentan-2-yl]-8-hydroxy-3,15-dimethoxy-5,7,9,11-tetramethyl-1-oxacyclohexadeca-3,5,11,13-tetraen-2-one
Chemical Formula
C35H58O9
Molecular Weight
622.8 Da
Appearance
White solid
Purity
>95% by HPLC
Solubility
Soluble in ethanol, methanol, DMF or DMSO. DMSO @ 50mg/ml. Poor water solubility.
Storage Temp
-20°C
THERAPEUTIC AREA
Oncological Disorders
USE
Bafilomycin A1 inhibit macroautophagy and promote apoptosis in colon cancer cells. Baf A1 inhibits the action of Tentanus toxin in spinal cord neurons in cell culture. It also inhibits rhinovirus infection in human airways.
MDL NUMBER
MFCD06795130
CHEMACX
X1087211-6
INCHI
InChI=1S/C35H58O9/c1-19(2)32-24(7)27(36)18-35(40,44-32)26(9)31(38)25(8)33-28(41-10)14-12-13-20(3)15-22(5)30(37)23(6)16-21(4)17-29(42-11)34(39)43-33/h12-14,16-17,19,22-28,30-33,36-38,40H,15,18H2,1-11H3/b14-12+,20-13+,21-16+,29-17-/t22-,23+,24-,25-,26-,27+,28-,30-,31+,32+,33+,35+/m0/s1
SMILES
C[C@H]1C/C(=C/C=C/[C@@H]([C@H](OC(=O)/C(=C/C(=C/[C@H]([C@H]1O)C)/C)/OC)[C@@H](C)[C@H]([C@H](C)[C@]2(C[C@H]([C@@H]([C@H](O2)C(C)C)C)O)O)O)OC)/C
Peptide sequence
Not Applicable
RTECS
Not Applicable
UN #'S
Not Applicable
PACKING GROUP
Not Applicable
HAZARD CLASS
Not Applicable
Handling
Warning; Toxic. May be Carcinogenic. Ensure adequate ventilation, especially in confined areas. Use personal protective equipment as required. Use with local exhaust ventilation. Do not breathe dust/fume/gas/mist/vapors/spray.
Key Words
Bafilomycin A1 , Mitochondrial uncoupling, neuronal cells, V-ATPase
Certificate of Analysis 1
Certificate of Analysis 2
Certificate of Analysis 3
GHS PICTOGRAMS | ![]() |
---|---|
Handling | Warning; Toxic. May be Carcinogenic. Ensure adequate ventilation, especially in confined areas. Use personal protective equipment as required. Use with local exhaust ventilation. Do not breathe dust/fume/gas/mist/vapors/spray. |
UN #'S | Not Applicable |
Packing Group | Not Applicable |
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