Bafilomycin B1

SKU
B-1185
  • CAS:88899-56-3
  • Formula:C44H65NO13
  • MW:816.0 Da
  • Appearance:White Powder
  • Purity:>95% by HPLC

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Product Name Qty
Bafilomycin B1
1 mg
$194.99
Bafilomycin B1
5 mg
$474.99

Bafilomycin B1 is a member of a potent family of macrocyclic lactones. Bafilomycin B1 shares the same mode of action and activity as its more accessible A1 analogue. Bafilomycin B1 is broadly active against bacteria, fungi, insects, nematodes and protozoans. Bafilomycin B1 has attracted interest as a potential agent for treating osteoporosis. Isolated from Streptomyces sp.

More Information
Alternate Name/Synonyms
Setamycin
SKU
B-1185
CAS #
88899-56-3
Chemical Name
[(2R,4R,5S,6R)-2-hydroxy-2-[(2S,3R,4S)-3-hydroxy-4-[(3S,4Z,6Z,9S,10S,11R,12Z,14E)-10-hydroxy-3,15-dimethoxy-7,9,11,13-tetramethyl-16-oxo-1-oxacyclohexadeca-4,6,12,14-tetraen-2-yl]pentan-2-yl]-5-methyl-6-propan-2-yloxan-4-yl] (E)-4-[(2-hydroxy-5-oxocyclope
Chemical Formula
C44H65NO13
Molecular Weight
816.0 Da
Appearance
White Powder
Purity
>95% by HPLC
Solubility
Soluble in ethanol, methanol, DMF or DMSO.
Storage Temp
-20°C, desiccated
THERAPEUTIC AREA
Antibacterial
USE
Bafilomycin B1, a plecomacrolide originally found to be produced by different Streptomyces species, has been shown to display activity against gram-positive bacteria and fungi. This compound is shown to be a potent and selective inhibitor of all V-ATPases. Studies have demonstrated that Bafilomycin B1 inhibits the osteoclastic proton pump in vitro. In addition, this compound has displayed a capacity to have concentration-dependent effects on neuronal cell viability. Bafilomycin B1 may also promote the accumulation of autophagic vacuoles and trigger Bax-dependent apoptosis.
Handling
Avoid contact with skin, eyes or clothing. Use personal protective equipment as required. Wash contaminated clothing before reuse. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this product.
Certificate of Analysis 1
Certificate of Analysis 2
Certificate of Analysis 3
GHS PICTOGRAMS
Handling Avoid contact with skin, eyes or clothing. Use personal protective equipment as required. Wash contaminated clothing before reuse. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this product.
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