BAPTA-FF(AM) is a membrane-permeable difluorinated derivative of BAPTA (acetoxymethyl ester). When hydrolyzed by cytosolic esterases, it becomes trapped in cell. BAPTA itself is now used essentially for buffering calcium, but the lower affinity fluoro derivatices-difluoro and tetrafluoro(BAPTA FF) have been a good source for studying high concentration of calcium using F NMR. 

Attached are a few published references from researchers who have used our BAPTA-FF (AM) product. We respectfully thank them for their trust in our product. Inquire for a full reference list. 

• MECHANISMS OF SIGNAL TRANSDUCTION:  Mechanical Compression of Cartilage Explants Induces Multiple Time-dependent Gene Expression Patterns and Involves Intracellular Calcium and Cyclic AMP, Jonathan B. Fitzgerald, et al., J. Biol. Chem., May 2004; 279: 19502 - 19511.

• GLYCOBIOLOGY AND EXTRACELLULAR MATRICES:  Shear and Compression Differentially Regulate Clusters of Functionally Related Temporal Transcription Patterns in Cartilage Tissue, Jonathan B. Fitzgerald, et al., J. Biol. Chem., Aug 2006; 281: 24095 - 24103.  

•  MEMBRANE TRANSPORT, STRUCTURE, FUNCTION, AND BIOGENESIS:  The Foot Structure from the Type 1 Ryanodine Receptor Is Required for Functional Coupling to Store-operated Channels, Alicia Sampieri, et al., J. Biol. Chem., Jul 2005; 280: 24804 - 24815.