SDS
CofA
An isoquinoline alkaloid that acts as an anticancer agent. It inhibits cell growth and induces apoptosis in a variety of cancer cell lines. It induces the most potent apoptosis in acute lymphoblastic leukemia (ALL) cells with both MDM2 overexpression and a wild-type (wt)-p53, whereas no pro-apoptotic effect was detected in ALL cells that were negative for MDM2 and wt-p53.
More Information
Alternate Name/Synonyms
Natural Yellow 18, 5,6-Dihydro-9,10-dimethoxybenzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium
SKU
B-2196
CAS #
633-65-8
Chemical Name
Natural Yellow 18, 5,6-Dihydro-9,10-dimethoxybenzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium
Chemical Formula
C20H18ClNO4
Molecular Weight
371.81
Appearance
Yellow to orange Solid
Purity
98% by TLC
Solubility
MeOH (50 mg/ml) or Water (~ 2 mg/ml)
Melting Point
193-196 °C
Storage Temp
-20°C
THERAPEUTIC AREA
Oncological Disorders
USE
Berberine is an isoqinoline alkaloid shown to have a chemopreventive property against colon tumor formation by inhibiting the enzyme Cox-2
MDL NUMBER
MFCD00011939
CHEMACX
X1006388-4
INCHI
InChI=1S/C20H18NO4.ClH/c1-22-17-4-3-12-7-16-14-9-19-18(24-11-25-19)8-13(14)5-6-21(16)10-15(12)20(17)23-2;/h3-4,7-10H,5-6,11H2,1-2H3;1H/q+1;
SMILES
COc1ccc2cc-3[n+](cc2c1OC)CCc4c3cc5c(c4)OCO5.Cl
Peptide sequence
Not Applicable
RTECS
DR9866400
UN #'S
Not Applicable
PACKING GROUP
Not Applicable
HAZARD CLASS
Not Applicable
Handling
Protect from air and light
Citations
MECHANISMS OF SIGNAL TRANSDUCTION:
A New Isoquinolinium Derivative, Cadein1, Preferentially Induces Apoptosis in p53-defective Cancer Cells with Functional Mismatch Repair via a p38-dependent Pathway
Eun Ryoung Jang, Minsook Ryu, Jeong Eun Park, Jung-Ho Kim, Jong-Soo Lee, and Kiwon Song
J. Biol. Chem., Jan 2010; 285: 2986 - 2995.
Citations_Hyperlink
http://www.jbc.org/cgi/reprint/285/5/2986
| Handling | Protect from air and light |
|---|---|
| UN #'S | Not Applicable |
| Packing Group | Not Applicable |
