Berberine Chloride

SKU

B-2196

CAS:633-65-8
Formula:C₂₀H₁₈ClNO₄
MW:371.81
Appearance:Yellow to orange Solid
Purity:98% by TLC

SDS

CofA

Product Name	Qty
Berberine Chloride 500 mg $222.12
Berberine Chloride 100 mg $62.65

Details

An isoquinoline alkaloid that acts as an anticancer agent. It inhibits cell growth and induces apoptosis in a variety of cancer cell lines. It induces the most potent apoptosis in acute lymphoblastic leukemia (ALL) cells with both MDM2 overexpression and a wild-type (wt)-p53, whereas no pro-apoptotic effect was detected in ALL cells that were negative for MDM2 and wt-p53.

Specifications

More Information

Alternate Name/Synonyms

Natural Yellow 18, 5,6-Dihydro-9,10-dimethoxybenzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium

SKU

B-2196

CAS #

633-65-8

Chemical Name

Natural Yellow 18, 5,6-Dihydro-9,10-dimethoxybenzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium

Chemical Formula

C₂₀H₁₈ClNO₄

Molecular Weight

371.81

Appearance

Yellow to orange Solid

Purity

98% by TLC

Solubility

MeOH (50 mg/ml) or Water (~ 2 mg/ml)

Melting Point

193-196 °C

Storage Temp

-20°C

THERAPEUTIC AREA

Oncological Disorders

USE

Berberine is an isoqinoline alkaloid shown to have a chemopreventive property against colon tumor formation by inhibiting the enzyme Cox-2

MDL NUMBER

MFCD00011939

CHEMACX

X1006388-4

INCHI

InChI=1S/C20H18NO4.ClH/c1-22-17-4-3-12-7-16-14-9-19-18(24-11-25-19)8-13(14)5-6-21(16)10-15(12)20(17)23-2;/h3-4,7-10H,5-6,11H2,1-2H3;1H/q+1;

SMILES

COc1ccc2cc-3[n+](cc2c1OC)CCc4c3cc5c(c4)OCO5.Cl

Peptide sequence

Not Applicable

RTECS

DR9866400

UN #'S

Not Applicable

PACKING GROUP

Not Applicable

HAZARD CLASS

Not Applicable

Handling

Protect from air and light

Citations

MECHANISMS OF SIGNAL TRANSDUCTION: A New Isoquinolinium Derivative, Cadein1, Preferentially Induces Apoptosis in p53-defective Cancer Cells with Functional Mismatch Repair via a p38-dependent Pathway Eun Ryoung Jang, Minsook Ryu, Jeong Eun Park, Jung-Ho Kim, Jong-Soo Lee, and Kiwon Song J. Biol. Chem., Jan 2010; 285: 2986 - 2995.

Citations_Hyperlink

http://www.jbc.org/cgi/reprint/285/5/2986

Reviews

Safety

Handling	Protect from air and light
UN #'S	Not Applicable
Packing Group	Not Applicable

Citations