BI-D1870

SKU
B-2201
  • CAS:501437-28-1
  • Formula:C19H23F2N5O2
  • MW:391.42
  • Appearance:Pale orange Solid
  • Purity:98% by TLC
Product Name Qty
BI-D1870
1 mg
$88.22
BI-D1870
5 mg
$318.27
Cell-permeable. ATP-competitive inhibitor of the four isoforms of ribosomal S6 kinase (p90 RSK) (IC's at 100 M ATP: RSK1 = 31 nM, RSK2 = 24 nM, RSK3 = 18 nM, RSK4 = 15 nM). Does not significantly inhibit 10 other AGC kinases, and over 40 other protein kinases at 100X concentrations. In addition, BI-D1870 completely prevents PMA-induced TSC2 (a regulator of mTORC1) phosphorylation at Ser.
More Information
Alternate Name/Synonyms
2-[(3,5-Difluoro-4-hydroxyphenyl)amino]-7,8-dihydro-5,7-dimethyl-8-(3-methylbutyl)-6(5H)-pteridone
SKU
B-2201
CAS #
501437-28-1
Chemical Name
2-[(3,5-Difluoro-4-hydroxyphenyl)amino]-7,8-dihydro-5,7-dimethyl-8-(3-methylbutyl)-6(5H)-pteridone
Chemical Formula
C19H23F2N5O2
Molecular Weight
391.42
Appearance
Pale orange Solid
Purity
98% by TLC
Solubility
Soluble in DMSO (>25 mg/ml)
Stability
N/A
Storage Temp
-20°C
THERAPEUTIC AREA
Not Available
USE
BI-D1870 is a cell permeable, ATP-competitive inhibitor of the four isoforms of ribosomal S6 kinase (p90 RSK) 
MDL NUMBER
MFCD11223662
CHEMACX
X1859206-0
INCHI
InChI=1S/C19H23F2N5O2/c1-10(2)5-6-26-11(3)18(28)25(4)15-9-22-19(24-17(15)26)23-12-7-13(20)16(27)14(21)8-12/h7-11,27H,5-6H2,1-4H3,(H,22,23,24)
SMILES
CC1C(=O)N(c2cnc(nc2N1CCC(C)C)Nc3cc(c(c(c3)F)O)F)C
Peptide sequence
Not Applicable
RTECS
Not Applicable
UN #'S
Not Applicable
PACKING GROUP
Not Applicable
HAZARD CLASS
Not Applicable
Handling
Protect from light and air
Promo text for AGS discount
N/A
GHS PICTOGRAMS
Handling Protect from light and air
UN #'S Not Applicable
Packing Group Not Applicable
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