BIBW2992 (Afatinib)

SKU
B-2200
  • CAS:439081-18-2
  • Formula:C24H25ClFN5O3
  • MW:485.94
  • Appearance:Crystalline Solid
  • Purity:99%
Product Name Qty
BIBW2992
5 mg
$1,019.47
BIBW2992
1 mg
$336.03

BIBW-2992 is a potent irreversible EGFR/HER2 inhibitor. The potency of BIBW-2992 on the EGFR and HER2 kinases revealed ICvalues of 0.5 nM and 14 nM, respectively. BIBW-2992 is highly selective for these kinases and no additional inhibition of other kinases has been observed.

More Information
Alternate Name/Synonyms
Tovok
SKU
B-2200
CAS #
439081-18-2
Chemical Name
4-[(3-CHLORO-4-FLUOROPHENYL)AMINO]-6-([4-(N,N-DIMETHYLAMINO)-1-OXO-2-BUTEN-1-YL]AMINO)-7-((S)-TETRAHYDROFURAN-3-YLOXY)-QUINAZOLINE
Chemical Formula
C24H25ClFN5O3
Molecular Weight
485.94
Appearance
Crystalline Solid
Purity
99%
Solubility
DMSO
Storage Temp
-20°C
THERAPEUTIC AREA
Oncological Disorders
USE
An irreversible and potent EGFR/Neu inhibitor, inhibits EGFR phosphorylation used in cancer
MDL NUMBER
MFCD12407405
CHEMACX
X1812388-7
INCHI
InChI=1S/C24H25ClFN5O3/c1-31(2)8-3-4-23(32)30-21-11-17-20(12-22(21)34-16-7-9-33-13-16)27-14-28-24(17)29-15-5-6-19(26)18(25)10-15/h3-6,10-12,14,16H,7-9,13H2,1-2H3,(H,30,32)(H,27,28,29)/b4-3+/t16-/m0/s1
SMILES
CN(C)C/C=C/C(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)O[C@H]4CCOC4
Handling
Protect from air and moisture
GHS PICTOGRAMS
HandlingProtect from air and moisture
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