Non-detergent sulfobetaines (NDSB) have a sulfobetaine hydrophilic groups similar to those of zwitterionic detergents and a short hydrophobic chains that cannot aggregate to form micelles. Therefore NDSB is not considered as detergent. They have been reported to improve the extraction yield of membrane, nuclear and cyto-skeletal associated proteins. NDSBs are used for protein folding, renaturation, and crystallization.
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