Bleomycin Sulfate

SKU
B-1269
  • CAS:9041-93-4
  • Formula:C55H84N17O21S3 · xH2SO4
  • MW:1415.55. x98.08
  • Appearance:White solid
  • Purity:≥90% (A2 + B2)

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Product Name Qty
Bleomycin Sulfate
10 mg
$315.00
Bleomycin Sulfate
5 mg
$175.00

Description

Bleomycin Sulfate is an anti-neoplastic antibiotic from Streptomyces verticillus. It binds to DNA and can inhibit DNA synthesis and causes scission of DNA. Able to cleave DNA and also RNA, but at less and more selective a degree. Also reported to induce and regulate apoptosis in a variety of cells, and inhibit tumor angiogenesis.

Produces double and single stranded DNA breaks. Inhibitis intracellular DNA replication. DNA alkylating agent.

Not for human therapeutic use or for medicinal purposes. For research applications only.

More Information
Alternate Name/Synonyms
Bleo; Blenoxane; Blexane
SKU
B-1269
CAS #
9041-93-4
Chemical Name
3-[[2-[2-[2-[[2-[[4-[[2-[[6-amino-2-[3-amino-1-[(2,3-diamino-3-oxopropyl)amino]-3-oxopropyl]-5-methylpyrimidine-4-carbonyl]amino]-3-[(2R,3S,4S,5S,6S)-3-[(2R,3S,4S,5R,6R)-4-carbamoyloxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5-dihydroxy-6-(hydroxym
Chemical Formula
C55H84N17O21S3 · xH2SO4
Molecular Weight
1415.55. x98.08
Appearance
White solid
Purity
≥90% (A2 + B2)
Solubility
Water (10 mg/mL)
Melting Point
200-204 °C
Preparation
Stock solutions can be store <3 months at +4C
Storage Temp
-20°C
THERAPEUTIC AREA
Oncological Disorders
USE
Anti-tumor antibiotic
MDL NUMBER
MFCD00070310
CHEMACX
X1017354-5
PubChecm ID
46930981
INCHI
InChI=1S/C55H83N17O2InChI=1S3.H2O4S/c1-20-33(69-46(72-44(20)58)25(12-31(57)76)64-13-24(56)45(59)82)50(86)71-35(41(26-14-61-19-65-26)91-54-43(39(80)37(78)29(15-73)90-54)92-53-40(81)42(93-55(60)88)38(79)30(16-74)89-53)51(87)66-22(3)36(77)21(2)47(83)70-34(23(4)75)49(85)63-10-8-32-67-28(18-94-32)52-68-27(17-95-52)48(84)62-9-7-11-96(5)6;1-5(2,3)4/h14,17-19,21-25,29-30,34-43,53-54,64,73-75,77-81H,7-13,15-16,56H2,1-6H3,(H13-,57,58,59,60,61,62,63,65,66,69,70,71,72,76,82,83,84,85,86,87,88);(H2,1,2,3,4)/t21-,22+,23-,24-,25+,29-,30-,34-,35+,36-,37+,38-,39-,40+,41?,42+,43-,53-,54-;/m1./s1
SMILES
CC1=C(N=C(N=C1N)C(CC(=O)N)NCC(C(=O)N)N)C(=O)NC(C(C2=CN=CN2)OC3C(C(C(C(O3)CO)O)O)OC4C(C(C(C(O4)CO)O)OC(=O)N)O)C(=O)NC(C)C(C(C)C(=O)NC(C(C)O)C(=O)NCCC5=NC(=CS5)C6=NC(=CS6)C(=O)NCCC[S+](C)C)O.OS(=O)(=O)[O-]
RTECS
EC5991990
Handling
Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed. Normal measures for preventive fire protection. TOXIC.
Certificate of Analysis 1
Certificate of Analysis 2
Certificate of Analysis 3
GHS PICTOGRAMS
Handling Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed. Normal measures for preventive fire protection. TOXIC.
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