Bleomycin Sulfate

SKU
B-1269
  • CAS:9041-93-4
  • Formula:C55H84N17O21S3 · xH2SO4
  • MW:1415.55. x98.08
  • Appearance:White Crystalline / Powder
  • Purity:≥90%

0

0

0

0

Product Name Qty
Bleomycin Sulfate
10 mg
$185.00

Anti-neoplastic antibiotic from streptomyces verticillus, mixture of Bleomycin A2, B2, B4. Bleomycin sulfate binds to DNA, and can inhibit DNA synthesis and causes scission of DNA. Cleaves DNA, requires binding to oxygen and a metal ion, such as copper or iron. Able to cleave RNA, but at lessand more selective degree. Also reported to induce and regulate apoptosis in a variety of cells, and inhibit tumor angiogenesis.

More Information
Alternate Name/Synonyms
Bleo; Blenoxane; Blexane
SKU
B-1269
CAS #
9041-93-4
Chemical Name
3-[[2-[2-[2-[[(2R,3R)-2-[[(2S,3S,4R)-4-[[(2R,3R)-2-[[6-AMINO-2-[(1S)-3-AMINO-1-[[(2S)-2,3-DIAMINO-3-OXOPROPYL]AMINO]-3-OXOPROPYL]-5-METHYLPYRIMIDINE-4-CARBONYL]AMINO]-3-[(2R,3S,4S,5S,6S)-3-[(2S,3S,4R,5R,6R)-4-CARBAMOYLOXY-3,5-DIHYDROXY-6-(HYDROXYMETHYL)OX
Chemical Formula
C55H84N17O21S3 · xH2SO4
Molecular Weight
1415.55. x98.08
Appearance
White Crystalline / Powder
Purity
≥90%
Solubility
Soluble in water (20 mg/ml).
Melting Point
200-204 °C
Preparation
Stock solutions can be store <3 months at +4C
Storage Temp
-20°C
THERAPEUTIC AREA
Oncological Disorders
USE
Bleomycin Sulfate is anti-neoplastic antibiotic from streptomyces verticillus
MDL NUMBER
MFCD00070310
CHEMACX
X1017354-5
INCHI
InChI=1S/2C55H83N17O21S3.H2O4S/c2*1-20-33(69-46(72-44(20)58)25(12-31(57)76)64-13-24(56)45(59)82)50(86)71-35(41(26-14-61-19-66-26)91-54-43(39(80)37(78)28(16-73)90-54)92-53-40(81)42(93-55(60)88)38(79)29(17-74)89-53)51(87)67-22(3)36(77)21(2)47(83)70-34(23(4)75)49(85)63-10-8-32-68-27(18-94-32)52-65-15-30(95-52)48(84)62-9-7-11-96(5)6;1-5(2,3)4/h2*14-15,18-19,21-25,28-29,34-43,53-54,64,73-75,77-81H,7-13,16-17,56H2,1-6H3,(H13-,57,58,59,60,61,62,63,66,67,69,70,71,72,76,82,83,84,85,86,87,88);(H2,1,2,3,4)/t2*21-,22+,23+,24-,25-,28-,29+,34+,35+,36-,37+,38+,39-,40-,41-,42+,43-,53-,54-;/m00./s1
SMILES
Cc1c(nc(nc1N)[C@H](CC(=O)N)NC[C@@H](C(=O)N)N)C(=O)N[C@H]([C@H](c2cnc[nH]2)O[C@H]3[C@H]([C@H]([C@@H]([C@@H](O3)CO)O)O)O[C@H]4[C@H]([C@@H]([C@@H]([C@H](O4)CO)O)OC(=O)N)O)C(=O)N[C@H](C)[C@H]([C@H](C)C(=O)N[C@H]([C@@H](C)O)C(=O)NCCc5nc(cs5)c6ncc(s6)C(=O)NCCC[
Peptide sequence
Not Applicable
RTECS
EC5991990
UN #'S
Not Applicable
PACKING GROUP
Not Applicable
HAZARD CLASS
Not Applicable
Handling
Store tightly sealed. TOXIC.
Certificate of Analysis 1
Certificate of Analysis 2
Certificate of Analysis 3
GHS PICTOGRAMS
Handling Store tightly sealed. TOXIC.
UN #'S Not Applicable
Packing Group Not Applicable
To Top