AG Scientific is a leading supplier of the immunosuppressant, FK-506 commonly known as Tacrolimus. It is well known for its ability to prevent allograft rejection after transplantation. AG Scientific has long been established as a leading research supplier in the field of fermentation derived secondary metabolites. One line of immunosuppressants is particularly impressive. Products include: FK-506, Rapamycin, Bafilomycins, Mitomycins, Neomycin, Mycophenolic, Trichosatatins, and much, much more.
We offer a range of catalog sizes, as well as, multi-kilogram quantities for bulk applications. Additionally, we provide a full service of bottling, sterile formulations, custom packaging, as well as, comprehensive private labeling capabilities.
FK-506, is a product for which we often get questions on the following: solution preparation, storage, stability, handling, trouble shooting, how to avoid common mistakes. Here are the most popular issues we know you need to know prior to using FK-506. We've included all the appropriate answers, as well as, a Material Safety Data Sheet (MSDS) to ease your research.
QUESTION: What is FK-506?
ANSWER: FK-506, Tacrolimus is a calcineurin inhibitor that has been widely used to prevent allograft rejection after transplantation. FK-506 is an immunosuppressive drug that is mainly used after allogeneic organ transplant to reduce the activity of the patient's immune system and so lower the risk of organ rejection. It is also used in a topical preparation in the treatment of atopic dermititis (eczema), severe refractory uveitis after bone marrow transplants, and the skin condition vitiligo.
Although short-term immunosuppression concerning patient and graft survival is found to be similar between the two drugs, cyclosporine & fk-506 results in a more favorable lipid profile, and this may have important long-term implications given the prognostic influence of rejection on graft.
QUESTION: Does the immunosuppressant, FK-506 go by another name?
ANSWER: Yes, most popularly known as, Tacrolimus, but also known as Fujimycin, FR900506, Prograf, Protopic, L 679934.
QUESTION: What is FK-506 chemical formula, molecular weight, melting point?
ANSWER: C44H69NO12, M.W. 804.03, Melting Point.
QUESTION: Why do I see M.W. of 804.03 vs. 822.03?
ANSWER: Some report M.W.804 less the water, see Merck Index 14th edition, 9025; CAS [104987-11-3]; however, tacrolimus has an empirical formula of C44H69NO12 H2O, Tacrolimus.monohydrate and a formula weight of 822.03, CAS [109581-93-3].
QUESTION: What can you tell me about FK-506 solubility?
ANSWER: Soluble in Methanol, Ethanol (25 mg/ml), Acetone, Ethyl Acetate, Diethyl ether, Chloroform, Dicloromethane. Sparingly soluble in Hexane, Petroleum ether. Insoluble in water. Clear colorless solution at 10 mg/ml of: Dichloromethane, Ethyl Acetate, DMSO (25mg/ml).
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