1. Proteomics for Cancer Biomarker Discovery - Pt. 1

    Cancer remains a major public health challenge despite progress in detection and therapy. A large portion of the US population will develop cancer during their lifetime, with ∼500 000 individuals dying annually from the disease. The race to obtain control over the disease process is gaining speed and focus. From biotechnology to chemistry, from applied physics to software, increasing resources are being brought to bear on the goals of prevention and reducing mortality. Innovations and applications of biotechnology have allowed the exploitation of biological processes in an effort to study pathogenesis at the molecular level. Novel technologies that are designed to advance the molecular analyses of healthy and diseased human cells are poised to revolutionize the field of health and disease. Advances in the fields of genomics and proteomics are hoped to provide insights into the molecular complexity of the disease process and thus enable the development of tools to help in treatment as well as in detection and prevention.
  2. Ruboxistaurin: LY-333531

    Ruboxistaurin: LY333531, an orally active protein kinase C beta (PKC beta) inhibitor, is a macrocyclic bisindolylmaleimide compound under development by Eli Lilly with potential as a therapy for diabetic macular oedema and other diabetic angiopathies, including diabetic retinopathy, diabetic peripheral neuropathy and diabetic nephropathy.
  3. MicroRNAs: from single biomarkers to re-wired networks

    The complexity of higher organisms is regulated through the coordinated control of biological networks, including miRNAs. Computational networks have previously been generated using miRNA array data. For the first time, we have applied a similar approach to circulating miRNAs.
  4. Sudden Infant Death Syndrome, (SIDS) a personal story from grief to hope

    It’s been almost 13 years since we lost our daughter, Daly Alexandra Lindgren, to SIDS. She was 3 months old. What is SIDS? SIDS is Sudden Infant Death Syndrome. Some people call it crib death.
  5. Epigenetics reinforces theory that positive thinking heals

    There was a time where love and nurture seemed clearly distinct from our physical nature. Genetic-determinism holds that genes control our lives; hereditary information flows in one direction, and genetic activity and cellular expression are regulated by information from the DNA.
  6. Epigenetic 'Memory' Key to Nature Versus Nurture

    "There are quite a few examples that we now know of where the activity of genes can be affected in the long term by environmental factors. And in some cases the environment of an individual can actually affect the biology or physiology of their offspring but there is no change to the genome sequence."
  7. Robotnikinin: The inhibitor of Sonic Hedgehog signaling (Shh)

    The purpose of this page is to describe the protein Sonic Hedgehog (shh). Secondary goals include a discussion of mutants and a brief description of two shh homologues.
  8. Ensure proper use of Orlistat, O-1106

    Xenical Orlistat works on your digestive system to help prevent the absorption of one-third of the dietary fat. The undigested fat passes out of the body through bowel-movement. Thus by reducing your calorie in-take Xenical Orlistat helps you to gradually lose weight.
  9. Blockade of Hsp90 by 17AAG antagonizes MDMX and synergizes with Nutlin to induce p53-mediated apoptosis in solid tumors

      Strategies to induce p53 activation in wtp53-retaining tumors carry high potential in cancer therapy. Nutlin, a potent highly selective MDM2 inhibitor, induces non-genotoxic p53 activation. Although Nutlin shows promise in promoting cell death in hematopoietic malignancies, a major roadblock is that most solid cancers do not undergo apoptosis but merely reversible growth arrest. p53 inhibition by unopposed MDMX is...
  10. LY294002 - Cell Permeable Inhibitor of Phosphatidylinositol 3-Kinase (PI3K)

    LY294002 is a morpholine derivative of quercetin. It is a potent inhibitor of phosphoinositide 3-kinases (PI3Ks). PI3Ks (phosphatidylinositol 3-kinases) is an enzyme implicated in growth factor signal transduction by associating with receptor and nonreceptor tyrosine kinases, including the platelet-derived growth factor receptor. Inhibitors of PI3Ks could potentially give a better understanding of the function and regulatory mechanisms of the enzyme. The PI3Ks (phosphatidylinositol 3-kinases) regulate...

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