The naturally occurring dietary compound, trans-resveratrol (trans-3,4',5-trihydroxystilbene), a natural phytoalexin present in grape skins, red wines, and grape juices, is sold over the counter in the United States as a nutritional supplement.
- Quinomycin A, also referred to as Echinomycin, is a peptide antibiotic which binds strongly to double-helical DNA up to a limit of approximately one molecule per five base-pairs. There is no detectable interaction with rRNA and only extremely feeble non-specific interaction with poly(rA) .poly(rU).
- Researchers have achieved a feat drug developers had thought difficult, if not impossible, discovering a compound that blocks the functioning of a key developmental protein by binding to an â€œundruggableâ€ target â€” an advance that may provide a new avenue to fight skin, pancreatic, prostate, and other cancers.
- Challenges The global study of proteins has many unique difficulties that set it apart from comprehensive studies of genes and transcripts. One difficulty is that the behavior of proteins is determined by the tertiary structure of the molecule. Any assay based on protein binding depends on maintaining the native conformation of the protein. This puts constraints on the systems...
- Necrosis is the premature death of cells in living tissue and can be caused by external factors to the cell or tissue, such as infection, toxins, cancer, infarction, poisons, ROS (Reactive Oxygen Species), inflammation or trauma. Necrosis inhibitors can counteract the effects that may normally cause cell death. Historically, cell death has been subdivided into regulated (apoptosis, AKA programmed...