1. Antibiotics Against Mycobacteria

    Mycobacterium is a genus of Actinobacteria, given its own family, the Mycobacteriaceae. The genus includes pathogens known to cause serious diseases in mammals, including tuberculosis (Mycobacterium tuberculosis) and leprosy (Mycobacterium leprae).
  2. Cancer Treatment Combination of Paclitaxel, Rapamycin and 17-AAG

    The Wisconsin Alumni Research Foundation (WARF) is seeking commercial partners interested in developing a composition of the synergistic anticancer agents rapamycin, paclitaxel and 17-AAG, encapsulated and solubilized by nontoxic, nanoscale PEG-b-PLA micelles.
  3. Polyether Ionophore Antibiotics

    The ionophores were first recognized as being a separate class with the publication of the structure for monensin in 1967. Several members of the group have found commercial application as anticoccidials in poultry farming and as growth promoters for cattle, pigs and chickens.

    17-allylamino,17-demethoxygeldanamycin (17-AAG) is a novel anticancer drug that is a less toxic analogue of the geldanamycin which binds to Hsp90 and alters its function. HSP90 client proteins play important roles in the regulation of the cell cycle, cell growth, cell survival, apoptosis, and oncogenesis.
  5. Benzoquinonoid Ansamycins Antibiotics

    Ansamycins is a family of secondary metabolites that show antimicrobial activity against many gram-positive and some gram-negative bacteria and includes various compounds, among which: streptovaricins and rifamycins. In addition, these compounds demonstrate antiviral activity towards bacteriophages and poxviruses.
  6. Aminoglycosides/Aminoglysidic Antibiotics Overview

    Bacteriocidal antibiotics obtained from Streptomyces that inhibit protein synthesis in bacterial ribosomes and are effective against aerobic gram-negative bacilli. This group of antibiotics includes at least eight drugs: amikacin,gentamicin, kanamycin, neomycin, netilmicin, paromomycin, streptomycin, and tobramycin. All of these drugs have the same basic chemical structure.
  7. Paclitaxel - A Mitotic Inhibitor Used in Cancer Chemotherapy

    Paclitaxel, Taxus brevifolia, commonly known as the Pacific yew, is a member of the yew family (Taxaceae). It is a small, slow growing evergreen tree native to the northwestern United States (Wheeler et al., 1992).
  8. Piperlonguminine: Potential Treatment For Alzheimer's Disease

    Piperlonguminine is a potential novel therapeutic agent for Alzheimer's disease.  Extracellular deposits of A-beta in senile plaques of the cerebral cortex are known to be hallmarks of Alzheimer's disease. Recent studies show that a mix of piperlonguminine and dihydropiperlonguminine significantly inhibit the expression of Amyloid Precursor Protein (APP). The decreased production of the peptide Amyloid-beta (A-beta) in SK-N-SH cells is...
  9. Veratramine: Hedgehog Signaling Pathway Inhibitor

    Veratramine is a teratogenic steroid alkaloid found in plants of the genus Veratrum. The Veratrum genus is one of coarse, highly poisonous herbs, also known as corn lilies. It is their toxic characteristic that has made them an interesting target for research in a variety of areas, including cancer research and cardiovascular research, and the full extent of its applications is still being studied.

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