1. 5 VITAL ACTINONIN APPLICATIONS

    Actinonin is a naturally occurring antibacterial agent that has demonstrated anti-tumor activity. The natural product peptidimetic actinonin demonstrates antiproliferative, antiangiogenic, and antimetastatic properties against many human cancers, including leukemia and lymphoma, as well as against lung and prostate tumors, both in vitro and in vivo.
  2. AEBSF AS A KEY BIOMARKER

    AEBSF or 4-(2-Aminoethyl) benzenesulfonyl fluoride hydrochloride is a water-soluble, irreversible serine protease inhibitor with a molecular weight of 239.5 Da. It inhibits proteases like chymotrypsin, kallikrein, plasmin, thrombin, and trypsin. The specificity is similar to the inhibitor PMSF, nevertheless, AEBSF is more stable at low pH values. Typical usage is 0.1 - 1.0 mM. AEBSF is used as a protease...
  3. 26 FAQS on Octyl-glucoside, (OG) biodetergent

    A non-ionic detergent intended for solubilizing membrane-bound proteins in theirnative state and for the preparation of lipid vesicles. Its well defined chemical structure, small uniform micelles and high water solubility make it superior to most other non-ionic detergent for membrane solubilization.
  4. 4 FACTS YOU SHOULD KNOW ABOUT ASCOMYCIN

    Ascomycin, also called Immunomycin, FR-900520, FK520, is an ethyl analog of tacrolimus (FK506) with strong immunosuppressant properties. Ascomycin acts by binding to immunophilins, especially macrophilin-12. It appears that Ascomycin inhibits the production of Th1 (interferon- and IL-2) and Th2 (IL-4 and IL-10) cytokines. Additionally, ascomycin preferentially inhibits the activation of mast cells, an important cellular component of the atopic response. Ascomycin produces a more selective immunomodulatory effect in that it inhibits the elicitation phase of allergic contact dermatitis but does not impair the primary immune response when administered systemically.
  5. 31 FAQs on Niclosamide

    Niclosamide is a STAT3 signaling pathway inhibitor. Displays selectivity for STAT3 over STAT1, STAT5, JAK1, JAK2 and Src kinases. Niclosamide potently inhibits the activation and transcriptional function of STAT3 and induces cell growth inhibition, apoptosis, and cell cycle arrest of cancer cells with constitutively active STAT3.
  6. 8 Anisomycin Media Applications!

    1. By inhibiting protein synthesis, anisomycin can prevent the expression of DNA. Protozoans and fungi are vulnerable to the compound, and when researchers originally discovered it in the 1950s, it was proposed for use against these infectious agents. In the lab, researchers can use anisomycin in experiments where they want to be able to inhibit DNA synthesis, for activities like isolating living organisms in culture. Laboratory suppliers with lines of biological compounds sell anisomycin intended for laboratory use through their catalogs.
  7. Dorsomorphin FAQS (Frequently Asked Questions)

    Stemolecule Dorsomorphin dihydrochloride is a potent inhibitor of AMPactivated protein kinase (AMPK) (Ki=109nM) and bone morphogenic protein(BMP) signaling. Dorsomorphin was identified in a screen for compounds that perturb dorsoventral axis formation in zebrafish.
  8. Treating Cancer Using Epirubicidin

    MECHANISM OF ACTION: epirubicidin, anthracycline, antibiotics, anticancerThe mechanism of action of epirubicin appears to be related to its ability to bind to nucleic acids. It forms a complex with DNA by intercalation between base pairs, resulting in inhibition of DNA and RNA synthesis. Intercalation also triggers DNA cleavage by topoisomerase II, resulting in cytocidal activity.
  9. Doxorubicin in Cancer Chemotherapy

    Doxorubicin; trade name Adriamycin; also known as hydroxydaunorubicin, is a drug used in cancer chemotherapy. It is an anthracycline antibiotic, closely related to the natural product daunomycin, and like all anthracyclines, it works by intercalating DNA, while most serious adverse effect being life-threatening heart damage.
  10. DAUNORUBICIN: Chemotherapeutic Properties

    Daunorubicin or daunomycin (daunomycin cerubidine) is chemotherapeutic of the anthracycline family that is given as a treatment for some types of cancer. It is most commonly used to treat specific types of leukaemia (acute myeloid leukemia and acute lymphocytic leukemia). It was initially isolated from Streptomyces peucetius.

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