Marcus Hilton has probably been going blind since he was born, though he didn't really begin to notice that something was wrong until he was seven or eight. Several years after that, he was officially diagnosed with Stargardt disease, the leading cause of juvenile blindness. Thirty-four years of decline later, his retinas irreparably damaged, he is unable to drive, read fine print, or recognize people from a distance.
- Heat shock protein 90 (Hsp90) is an often-mentioned molecular chaperone. Heat shock protein 90 (Hsp90) exerts an important role in the maturation and stability of client proteins. Oncogenic client proteins, which are the target molecules of many anticancer compounds, and encompass dysregulated, mutated, and fusion proteins, are particularly dependent on Hsp90 for maintaining their conformation.