UC San Diego researchers say they've found an immune system molecule that directly kills chronic lymphocytic leukemia cells without harming healthy ones. The molecule, called a monoclonal antibody, is being readied for human clinical trials in the not-too-distant future, lead researcher Thomas J. Kipps said. Kipps holds the Evelyn and Edwin Tasch Chair in Cancer Research at the UCSD Moores...
- Leupeptin is a protease inhibitor that is produced naturally by some species of the soil bacteria Streptomyces and thus inhibits the degradation of proteins. Unlike many synthetic protease inhibitors, it has very low toxicity to humans. This compound has been shown in research on animal models to protect hair cells in the ear from being killed by loud noise as well as certain antibiotics, and in turn prevents hearing loss.
- X-gal is an analog of lactose, and therefore may be hydrolyzed by the Î²-galactosidase enzyme which cleaves the Î²-glycosidic bond in D-lactose.
- Bestatin, Ubenimex: Bestatin, a small molecular weight dipeptide, is a potent inhibitor of various aminopeptidases, as well as, LTA4 hydrolase and Aminopeptidase N (APN/CD13). Bestatin is an immunomodifier. Bestatin also acts an immunorestorator and curative or preventive agent for spontaneous tumor.