Immunosuppressive drugs orĀ immunosuppressive agents are drugs that inhibit or prevent activity of the immune system.

What do immunosuppressants do?

1. Prevent the rejection of transplanted organs and tissues (e.g., bone marrow, heart, kidney, liver)

2. Treat autoimmune diseases or diseases that are most likely of autoimmune origin (e.g., rheumatoid arthritis, multiple sclerosis, myasthenia gravis, systemic lupus erythematosus, sarcoidosis, focal segmental glomerulosclerosis, Crohn's disease, Behcet's Disease, pemphigus, and ulcerative colitis)

3. Treat some other non-autoimmune inflammatory diseases (e.g., long term allergic asthma control)

4. Treat some other non-autoimmune inflammatory diseases (e.g., long term allergic asthma control)

A common side-effect of many immunosuppressive drugs is immunodeficiency, because the majority of them act non-selectively, resulting in increased susceptibility to infections and decreased cancer immunosurveillance. There are also other side-effects, such as hypertension, dyslipidemia, hyperglycemia, peptic ulcers, lipodystrophy, moon face, liver and kidney injury. The immunosuppressive drugs also interact with other medicines and affect their metabolism and action. Actual or suspected immunosuppressive agents can be evaluated in terms of their effects on lymphocyte subpopulations in tissues using immunohistochemistry.

Immunosuppressive drugs can be classified into five groups:

  • glucocorticoids
  • cytostatics
  • antibodies
  • drugs acting on immunophilins
  • other drugs.

Immunosuppression involves an act that reduces the activation or efficacy of the immune system. Some portions of the immune system itself have immuno-suppressive effects on other parts of the immune system, and immunosuppression may occur as an adverse reaction to the treatment of other conditions.
In general, deliberately induced immunosuppression is performed to prevent the body from rejecting an organ transplant, treating graft-versus-host disease after a bone marrow transplant, or for the treatment of auto-immune diseases such as rheumatoid arthritis or Crohn's disease. This is typically done using drugs but may involve surgery (splenectomy), plasmapharesis, or radiation.

 

Sources: Fimmel, S; Zouboulis CC (2005).

Desc

13 Items

per page
  1. NDSB-195, (Non-Detergent SulphoBetaines)
    NDSB-195, (Non-Detergent SulphoBetaines)
    D-1089

    Starting at $83.75

  2. Triptolide & analogs | CAS [38748-32-2] | Immunosuppressant, Apoptosis inducer. Offered by A.G.Scientific.
    Triptolide
    T-1030

    Starting at $89.34

  3. ASCOMYCIN STRUCTURE, | CAS [11011-38-4]| Immunosuppressant| Immunomycin, FK520, A.G. Scientific
    Ascomycin, Streptomyces hygroscopicus var ascomyceticus
    A-1258

    Starting at $35.00

  4. Mizoribine
    Mizoribine
    M-1217

    Starting at $139.59

  5. Myriocin | CAS [35891-70-4] | Potent immunosuppressant | A.G. Scientific
    Myriocin, Mycelia sterilia
    M-1235

    Starting at $83.75

  6. Cyclosporin C chemical structure | CAS 59787-61-0 | Potent Immunosuppressor | AG Scientific, Inc.
    Cyclosporin C
    C-1664

    Starting at $140.00

  7. Everolimus
    Everolimus
    E-2309

    Starting at $128.43

  8. Rocaglamide
    Rocaglamide
    R-2420

    Starting at $385.28

  9. Cyclosporin B
    Cyclosporin B
    C-2695

    Starting at $145.17

  10. Dihydrocyclosporin A
    Dihydrocyclosporin A
    D-2513

    Starting at $145.17

  11. Prodigiosin
    Prodigiosin
    P-2789

    Starting at $297.58

  12. Stachybotrylactam
    Stachybotrylactam
    S-2805

    Starting at $270.53

  13. Mycophenolic Acid | CAS 24280-93-1 | Renal Immunosuppressive | AG Scientific, Inc.
    Mycophenolic Acid (MPA)
    M-1036

    Starting at $117.30

Desc

13 Items

per page