Rolipram is commonly known as a drug used to treat depression. It is in the family of drugs referred to as monoamine oxidase inhibitors (MAOI). It promotes the release of norepinepherine, which in term produces a better mood and an alleviation of depression symptoms. Rolipram is actually a selective phosphodiesterase inhibitor and it inhibits phosphodiesterase IV or PDE-IV, particularly the PDE-IVB subtype. Like most PDE4-inhibitors, it is an anti-inflammatory drug. Rolipram has been studied as a possible antidepressant, and it also has anti-inflammatory, immunosuppressive, and anti-tumor effects. Rolipram has also been proposed as a treatment for multiple sclerosis, as well, and recent studies show that rolipram may have antipsychotic effects.
- Protein purification is a series of processes intended to isolate a single type of protein from a complex mixture. Protein purification is vital for the characterization of the function, structure and interactions of the protein of interest.
- The Phosphatase Inhibitor Cocktail (100X) is composed of a proprietary mix of sodium fluoride, sodium pyrophosphate, Î²-glycerophosphate, and sodium orthovanadate to promote broad spectrum protection against endogenous serine/threonine and tyrosine phosphatases.
- Rapamycin, also known as sirolimus, is an immunosuppressant drug used to prevent rejection in organ transplantation; it is especially useful in kidney transplants.