In a recent study published in the journal Proceedings of the National Academy of the Sciences, the research group of Professor Michael Hall from the University of Basel has shed light on the role of mTORC1 signaling in blood, and the relevance role it has for the physiology of, in this case, human liver cancers . Pictured: Human liver tumor...
- The European Court of Justice ruled yesterday that human reproductive stem cells which are not capable of developing into human beings can be patented. This is an important decision for local Carlsbadâ€™s International Stem Cell Corp.
- Studying the dynamics of how molecules fold and unfold has always been a struggle for Scientists due to their small size and rapid movement. Researchers from The Scripps Research Institute have collaborated with the University of California San Diego (UCSD) to develop a technique, referred to as temperature-jump, which allows the movement of these molecules to be studied.
- The richest physician in the world and founder of NantWorks, who is worth $12.9bn according to Forbes Magazine, has decided to invest in Sorrento Therapeutics. Dr. Patrick Soon-Shiong will buy 19.9% of Sorrento Therapeuticsâ€™ equity through the purchase of stocks at $5.80 per share. The agreement aims to help in the development of several drugs in the pipeline for cancer and autoimmune diseases.
- When cancer cells start to grow uncontrollably, the mTORnormal checkpoints and developmental programming become hijacked by signals emitted from the tumorous growth. One common side effect of chemotherapy and other forms of cancer treatment is drug-resistance. Usually during therapy, a second cancer-signaling pathway is opened as soon as the primary one shuts down. The investigators of this research concluded that this creates, â€œan ingenious escape route for the cancer cell to survive
- Scientific Breakthrough of the Year has been awarded to researchers at Scripps Research Institute following an online public vote by Science magazine. The two scientists, Floyd Romesberg and Denis Malyshev, led a team involved in the production of an expanded genome.
- Researchers have identified mammalian target of rapamycin (mTOR) as an important mediator of tumor progression. Inhibitors of mTOR signaling may be a promising way to treat a significant number of patients suffering from breast cancer. More specifically, the phosphatidylinositol-3-kinase (PI3K)/protein kinase B (AKT)/mTOR pathway plays a critical role in multiple cellular functions including metabolism, proliferation, growth and survival . This is a highly conserved pathway in many cancers and is linked to drug-resistance, a common side-effect with many forms of cancer therapy.
- Sudden unexplained death among individuals is a long-standing mystery among forensic scientists. On June 26th in San Diego, Jason Lappies took a seat on his sofa to watch a World Cup Soccer match before his shift at work started. When his housemate returned later that day however, Jason remained lying on the sofa in the same position as that morning...
- When it comes to emerging fields of science, such as mechanobiology (the study of structural biology), having access to the newest biochemical reagents may be crucial part of your expermintal design. That's why one of the main services AG Scientific brings to the table is not only the latest in scientific research, but the latest in biochemical reagants, as well.
- Reading through the annual Top 10 innovations list produced by The Scientist it is clear to see that companies from San Diego make a prominent appearance this year. With half of the innovations featured hailing from the Californian city, it secures San Diego's fast-growing reputation as a biotechnology development center. The top 10 best life-science products produced in the last...