1. Learn how Buthionine Inhibits Cancer Cells

    L-Buthionine sulfoximine is a specific γ-glutamylcysteine synthetase inhibitor that blocks the rate-limiting step of glutathionine biosynthesis and in doing so depletes the intracellular glutathionine pool in both cultured cells and in whole animals. Glutathionine (GSH) is a water-soluble tripeptide composed of glutamine, cysteine, and glycine. Reduced glutathione is the most abundant intracellular small molecule thiol present in mammalian cells and it serves as a potent intracellular antioxidant protecting cells from toxins such free radicals. Changes in glutathionine homeostasis have been implicated in the etiology and progression of a
  2. Anisomycin Shown to Alter Memory Formation

    The broadly held idea that memory formation in the brain is the cause of protein synthesis was challenged in light of data released by US researchers. By injecting a protein synthesis inhibitor, Anisomycin, into the brain, researchers then found they could boost certain levels of neurotransmitters.
  3. Polyketide Enzymes Shuffle the Molecular Deck

    Our current knowledge... The applications of protein engineering can be found everywhere in biology. This field, known as proteomics, is a reliable means of producing novel molecules and has provided scientists a basic roadmap to understanding the essential properties of proteins. Therefore to attempt a complete survey of the land is fruitless. However, it is useful to note some specific...
  4. Anisomycin - Protein Synthesis Inhibitor

    A.G. Scientific, Inc. is pleased to offer Anisomycin (Product # A-1049), isolated and purified from Streptomyces griseolus. Anisomycin is a bacterial antibiotic which inhibits protein synthesis by binding to 60S ribosomal subunits and blocking peptide bond formation. This prevents protein elongation and causing polysome stabilization. This action of Anisomycin monitored the cells for chromosomal DNA degradation and apoptosis.1-5 Anisomycin has...
  5. Are Circadian Clocks the Basis for Inheritance?

    Life originated on Earth first because of light, as we discussed last week (How Did Protein Synthesis Originate?). Life originated in the presence of Earth’s day and night cycles that most present-day organisms (from bacteria to plants to animals) come equipped with a rich internal clock system that dictates many different behaviors at different times of the day.

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