1. CK-666: Inhibitor of Actin-Related Proteins

    CK-666: Inhibitor of Actin-Related Proteins
    Actin is a family of globular multi-functional proteins that form microfilaments. Microfilaments, also called actin filaments, are filaments in the cytoplasm of eukaryotic cells that form part of the cytoskeleton. Actin participates in many important cellular processes, including muscle contraction, cell motility, cell division and cytokinesis, vesicle and organelle movement, cell signaling, and the establishment and maintenance of cell junctions...
  2. SMER28- Enhancer of Autophagy

    SMER28- Enhancer of Autophagy
    SMER28 is a small-molecule enhancer (SMER) of autophagy that increases autophagosome synthesis and enhances clearance of aggregate-prone substrates, including those relevant to Huntington's, Parkinson's, and Alzheimer's diseases. It is a positive regulator of autophagy in a mechanism independent from the mTOR pathway. It increases autophagosome synthesis and enhances the clearance of model autophagy substrates such as A53T a-synuclein and mutant...

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