Bafilomycins are a family of toxic macrolide antibiotics isolated from Streptomyces species. AG Scientific offers several high-quality bafilomycin products.
Bafilomycins are a family of toxic macrolide antibiotics isolated from Streptomyces species. AG Scientific offers several high-quality bafilomycin products.Bafilomycins at AG Scientific
Product Number | Product Name |
B-1183 | Bafilomycin A1 |
B-1185 | Bafilomycin B1 |
B-1245 | Bafilomycin B2 |
B-2535 | Bafilomycin C1 |
B-2537 | Bafilomycin D |
Bafilomycins in Cancer Research
The most commonly used bafilomycin is bafilomycin A1 (Baf-A1). Baf-A1 is an autophagy inhibitor, cell growth inhibitor and apoptosis inducer. Up until 2016 there have been several papers and studies that provide evidence that Baf-A1 is an autophagy inhibitor that prevents cancer cell proliferation and tumor regrowth in different cancer cell lines such as gastric cancer cell lines, pediatric leukemia cell lines and other tumor models. But a more recent paper published in February 2017 by Polish scientists gives a different view of Baf-A1's effects on colon cancer cells. This latest study is centered on poor prognosis of colon cancer, and increased relapse rate after cessation of chemotherapy. The relapse is attributed to the senescent cancer cells (cells that have stopped replicating or have reached their maximum count of replication cycle). It has been shown that chemotherapy induces senescence in cancer cells which is called "therapy induced senescence" (TIS). Some of these senescent cancer cells transiently display stem cell-like properties such as tumorigenesis and tumor regrowth properties. Some cancer stem cells (CSCs) are quiescent or undergo slow cycling phase and hence, escape the therapeutic intervention which has been pointed out as the possible cause for tumor relapse.
References:
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- Was, Halina, et al. “Bafilomycin A1 Triggers Proliferative Potential of Senescent Cancer Cells in Vitro and in NOD/SCID Mice.” Oncotarget, vol. 8, no. 6, 21 Dec. 2016, pp. 9303–9322., doi:10.18632/oncotarget.14066.
- Li, Liang-Qing, et al. “Inhibition of Autophagy by Bafilomycin A1 Promotes Chemosensitivity of Gastric Cancer Cells.” Tumor Biology, vol. 37, no. 1, 2015, pp. 653–659., doi:10.1007/s13277-015-3842-z.