1. Bestatin (Ubenimex): Applications in Life Science Research

    Bestatin (Ubenimex): Applications in Life Science Research
    Bestatin, also known as Ubenimex, is a competitive protease inhibitor. It is an inhibitor of aminopeptidase B, leukotriene A4 hydrolase, aminopeptidase N. It is being studied for use in the treatment of acute myelocytic leukemia.
  2. Differences Between Necrosis and Necroptosis

    Differences Between Necrosis and Necroptosis
    Cell death has traditionally been subdivided into regulated (apoptosis) and unregulated (necrosis) forms. While apoptosis has always been recognized to be a pathway of highly orchestrated signaling events, necrosis or necrotic cell death is known as a fortuitous and unregulated means of cell death that is induced by nonspecific and nonphysiological stress.
  3. Rapamycin: Most Commonly Asked Questions

    Rapamycin: Most Commonly Asked Questions
    Discovery of Rapamycin Rapamycin is a macrocyclic triene antibiotic that binds to the cytosolic protein FK-binding protein 12 (FKBP12) and inhibits mTOR pathway by directly binding to the mTOR Complex 1 (mTORC1). It is a potent immunosuppressant having a variety of uses both in vitro and in vivo and is used to prevent organ rejection after transplantation. Chemical structure of...
  4. Calcium Ionophore CA 1001: Applications in Medical Devices

    Calcium Ionophore CA 1001: Applications in Medical Devices
    As a chemical ionophore, CA 1001 (Calcium Ionophore I) has proven to be a high-quality biochemical. Its high selectivity for calcium ions makes it a great option for use in applications requiring the detection of calcium. CA 1001 can be used in calcium detection medical devices as well as biological membrane transport studies. What is Calcium Ionophore CA 1001? Calcium...
  5. Ponasterone A - Insect Steroid Hormones and Gene Switching

    Ponasterone A - Insect Steroid Hormones and Gene Switching
    Insect steroid hormones, responsible for molting and metamorphosis, are known for their gene switching functionality. Researchers have benefited from using Ponasterone A, an insect steroid hormone, for medical research. From cancer prevention to therapeutic approaches in neurodegenerative diseases, Ponasterone A has played an important role in scientific studies. What is Ponasterone A? Insect steroid hormones also called ecdysteroids, are a...
  6. A Guide to Necroptosis Inhibitors

    There is extensive evidence that necrosis plays a prominent role in a wide range of human pathological conditions, such as myocardial infarct, ischemic injury and neurodegeneration. Therefore, development of necrosis inhibitors is of high interest.
  7. Guide to Necrosis Signaling Pathway Inhibitors

    Necrosis is the premature death of cells in living tissue and can be caused by external factors to the cell or tissue, such as infection, toxins, cancer, infarction, poisons, ROS (Reactive Oxygen Species), inflammation or trauma. Necrosis inhibitors can counteract the effects that may normally cause cell death.   Historically, cell death has been subdivided into regulated (apoptosis, AKA programmed...

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